F5132
Factor II from human plasma
lyophilized powder, 5-20 units/mg protein
Synonym(s):
Prothrombin
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About This Item
form
lyophilized powder
specific activity
5-20 units/mg protein
UniProt accession no.
foreign activity
factor X <0.01% of base activity
thrombin, none detected
storage temp.
−20°C
Gene Information
human ... F2(2147)
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Biochem/physiol Actions
Plasma phospholipid binding protein; binds to endothelial cells, promotes clotting on the cell surfaces.
Unit Definition
One unit is the amount contained in one mL of normal human plasma.
Reconstitution
When reconstituted with 1 ml of deionized water, solution will contain the indicated activity in 0.5 M NaCl, 0.05 M Tris-HCl, pH 8.0.
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Raúl H Morales-Borges
Puerto Rico health sciences journal, 31(4), 232-234 (2013-07-13)
Splenic infarction is rare and the prothrombin gene mutation (PGM) is not commonly observed in Puerto Rico. PGM is present in 1% of the general population, and in 7% of the people with deep venous thrombosis (DVT); it is found
G V Papatheodoridis et al.
Journal of hepatology, 31(4), 747-750 (1999-11-07)
We evaluated the efficacy of recombinant factor VII to correct impaired haemostasis in a patient with liver cirrhosis requiring an invasive procedure. A test intravenous bolus of 80 microg/kg of recombinant factor VII was given to a Jehovah's Witness, with
S L Field et al.
Blood, 94(10), 3421-3431 (1999-11-24)
Lupus anticoagulants (LA) are a family of autoantibodies that are associated with in vitro anticoagulant activity but a strong predisposition to in vivo thrombosis. They are directed against plasma phospholipid binding proteins, including prothrombin. We found that a murine monoclonal
Y Zhao et al.
Arthritis and rheumatism, 42(10), 2132-2138 (1999-10-19)
To test the hypothesis that some lupus anticoagulants are antiprothrombin antibodies, and that such antibodies enhance prothrombin binding to endothelial cells (EC) and thus promote clotting on the cell surface. We generated a monoclonal antiprothrombin antibody (designated IS6) from a
György Miklós Buzás
Orvosi hetilap, 154(21), 810-819 (2013-05-23)
Tumor markers are gene products which signal the occurrence of tumors in different organs as well as their response to surgery and chemotherapy. The discovery of tumor markers occurred after the demonstration of tumor-specific transplantation antigens in chemically or virally
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