UPF3B
UPF3 regulator of nonsense transcripts homolog B (yeast)
Synonyms:
HUPF3B, MRXS14, RENT3B, UPF3X
Species:
Human UPF3B (65109), Mouse Upf3b (68134), Rat Upf3b (313449), domestic cat UPF3B (101084940), cow UPF3B (616181), naked mole-rat Upf3b (101700790), Zebrafish upf3b (393929), dog UPF3B (481031), chicken UPF3B (100858231), sheep UPF3B (101101868)
UniProtKB ID:
Gene ID:
- Human(65109) Summary: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(68134) UPF3 regulator of nonsense transcripts homolog B (yeast)
- Rat(313449) UPF3 regulator of nonsense transcripts homolog B (yeast)
- domestic cat(101084940) UPF3 regulator of nonsense transcripts homolog B (yeast)
- cow(616181) UPF3 regulator of nonsense transcripts homolog B (yeast)
- naked mole-rat(101700790) UPF3 regulator of nonsense transcripts homolog B (yeast)
- Zebrafish(393929) UPF3 regulator of nonsense transcripts homolog B (yeast)
- dog(481031) UPF3 regulator of nonsense transcripts homolog B (yeast)
- chicken(100858231) UPF3 regulator of nonsense transcripts homolog B (yeast)
- sheep(101101868) UPF3 regulator of nonsense transcripts homolog B (yeast)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-UPF3B antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-UPF3B antibody produced in rabbit, Ab2, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-UPF3B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot