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Merck

UBR1

ubiquitin protein ligase E3 component n-recognin 1

Synonyms:
JBS
Species:
Human UBR1 (197131), Mouse Ubr1 (22222), Rat Ubr1 (499877), dog UBR1 (487521), domestic cat UBR1 (101081553), Horse UBR1 (100056497), Zebrafish ubr1 (568531), Domestic Rabbit UBR1 (100338337), sheep UBR1 (101119567), chicken UBR1 (423242) ...More
UniProtKB ID:
Q8IWV7, O60708, O75492, Q14D45, Q68DN9, Q8IWY6, Q96JY4
Gene ID:
  • Human(197131) Summary: The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008]
  • Mouse(22222) ubiquitin protein ligase E3 component n-recognin 1
  • Rat(499877) ubiquitin protein ligase E3 component n-recognin 1
  • dog(487521) ubiquitin protein ligase E3 component n-recognin 1
  • domestic cat(101081553) ubiquitin protein ligase E3 component n-recognin 1
  • Horse(100056497) ubiquitin protein ligase E3 component n-recognin 1
  • Zebrafish(568531) ubiquitin protein ligase E3 component n-recognin 1
  • Domestic Rabbit(100338337) ubiquitin protein ligase E3 component n-recognin 1
  • sheep(101119567) ubiquitin protein ligase E3 component n-recognin 1
  • chicken(423242) ubiquitin protein ligase E3 component n-recognin 1
  • domestic guinea pig(100715624) ubiquitin protein ligase E3 component n-recognin 1
  • cow(522464) ubiquitin protein ligase E3 component n-recognin 1
  • naked mole-rat(101719904) ubiquitin protein ligase E3 component n-recognin 1

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Antibodies

Product Number
Description
Species Reactivity
Application
HPA038838
Anti-UBR1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
SAB1408967
Monoclonal Anti-UBR1 antibody produced in mouse, clone 4G7, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
HPA038839
Anti-UBR1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
HPA046727
Anti-Ubr1 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
MABS1180
Anti-E3 ubiquitin-protein ligase UBR1 Antibody, clone 6H9.1, clone 6H9.1, from mouse,
Species Reactivity
human, rat
Application
immunohistochemistry
western blot

esiRNA

Product Number
Description
Species
EHU053301
MISSION® esiRNA, targeting human UBR1,
Species
human