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Merck

TMC8

transmembrane channel-like 8

Synonyms:
EV2, EVER2, EVIN2
Species:
Human TMC8 (147138), Mouse Tmc8 (217356), Rat Tmc8 (688276), domestic guinea pig Tmc8 (100724540), naked mole-rat Tmc8 (101698806), dog TMC8 (483342), cow TMC8 (513813), sheep TMC8 (101114540), domestic cat TMC8 (101080594)
UniProtKB ID:
Q8IU68, Q2YDC0, Q8IWU7, Q8N358, Q8NF04
Gene ID:
  • Human(147138) Summary: Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008]
  • Mouse(217356) transmembrane channel-like gene family 8
  • Rat(688276) transmembrane channel-like 8
  • domestic guinea pig(100724540) transmembrane channel-like 8
  • naked mole-rat(101698806) transmembrane channel-like 8
  • dog(483342) transmembrane channel-like 8
  • cow(513813) transmembrane channel-like 8
  • sheep(101114540) transmembrane channel-like 8
  • domestic cat(101080594) transmembrane channel-like 8

Custom & Knockdown Gene Products

  • siRNA

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
HPA054429
Anti-TMC8 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
PRS4605
Anti-EVER2 (ab1) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
PRS4657
Anti-EVER2 (ab2) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot

esiRNA

Product Number
Description
Species
EHU151511
MISSION® esiRNA, targeting human TMC8,
Species
human
EMU057951
MISSION® esiRNA, targeting mouse Tmc8,
Species
mouse