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Merck

SPG20

spastic paraplegia 20 (Troyer syndrome)

Synonyms:
SPARTIN, TAHCCP1
Species:
Human SPG20 (23111), Mouse Spg20 (229285), Rat Spg20 (295053), domestic guinea pig Spg20 (100726150), naked mole-rat Spg20 (101721028), chicken SPG20 (418902), dog SPG20 (477303), domestic cat SPG20 (101085013), Horse SPG20 (100062426), cow SPG20 (534027) ...More
UniProtKB ID:
Q8N0X7, O60349, Q86Y67, Q9H1T2, Q9H1T3
Gene ID:
  • Human(23111) Summary: This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome). [provided by RefSeq, Nov 2008]
  • Mouse(229285) spastic paraplegia 20, spartin (Troyer syndrome) homolog (human)
  • Rat(295053) spastic paraplegia 20 (Troyer syndrome)
  • domestic guinea pig(100726150) spastic paraplegia 20 (Troyer syndrome)
  • naked mole-rat(101721028) spastic paraplegia 20 (Troyer syndrome)
  • chicken(418902) spastic paraplegia 20 (Troyer syndrome)
  • dog(477303) spastic paraplegia 20 (Troyer syndrome)
  • domestic cat(101085013) spastic paraplegia 20 (Troyer syndrome)
  • Horse(100062426) spastic paraplegia 20 (Troyer syndrome)
  • cow(534027) spastic paraplegia 20 (Troyer syndrome)
  • sheep(101105830) spastic paraplegia 20 (Troyer syndrome)
  • Domestic Rabbit(100358128) spastic paraplegia 20 (Troyer syndrome)

Custom & Knockdown Gene Products

  • siRNA

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
HPA039053
Anti-SPG20 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
HPA039054
Anti-SPG20 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
SAB2501830
Anti-SPG20 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot

esiRNA

Product Number
Description
Species
EHU076581
MISSION® esiRNA, targeting human SPG20,
Species
human
EMU056851
MISSION® esiRNA, targeting mouse Spg20,
Species
mouse