RAN
RAN, member RAS oncogene family
Synonyms:
ARA24, Gsp1, TC4
Species:
Human RAN (5901), Mouse Ran (19384), Rat Ran (84509), fruit fly ran (44072), Zebrafish ran (30572), chicken RAN (396193), dog RAN (100499482), dog RAN (442976), domestic cat RAN (101080666), cow RAN (540457) ...More
UniProtKB ID:
Gene ID:
- Human(5901) Summary: RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]
- Mouse(19384) RAN, member RAS oncogene family
- Rat(84509) RAN, member RAS oncogene family
- fruit fly(44072) CG1404 gene product from transcript CG1404-RA
- Zebrafish(30572) ras-related nuclear protein
- chicken(396193) RAN, member RAS oncogene family
- dog(100499482) RAN, member RAS oncogene family
- dog(442976) RAN, member RAS oncogene family
- domestic cat(101080666) RAN, member RAS oncogene family
- cow(540457) RAN, member RAS oncogene family
- sheep(100302079) RAN, member RAS oncogene family
- naked mole-rat(101711994) RAN, member RAS oncogene family
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Ran Antibody, clone 6S5X5, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
western blot
Anti-RAN antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
canine, human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Ran antibody,Mouse monoclonal, clone ARAN1, purified from hybridoma cell culture,
Species Reactivity
xenopus, bovine, hamster, human, mouse
Application
ELISA
immunocytochemistry
immunoprecipitation (IP)
microarray
western blot
immunocytochemistry
immunoprecipitation (IP)
microarray
western blot