PRF1
perforin 1 (pore forming protein)
Synonyms:
FLH2, HPLH2, P1, PFN1, PFP
Species:
Human PRF1 (5551), Mouse Prf1 (18646), Rat Prf1 (50669), Thale Cress PRF1 (816495), chicken PRF1 (427784), domestic guinea pig Prf1 (100730283), sheep PRF1 (101110903), cow PRF1 (369025), Horse PRF1 (100072744), domestic cat PRF1 (100113473) ...More
UniProtKB ID:
Gene ID:
- Human(5551) Summary: The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
- Mouse(18646) perforin 1 (pore forming protein)
- Rat(50669) perforin 1 (pore forming protein)
- Thale Cress(816495) profilin 1
- chicken(427784) perforin 1 (pore forming protein)
- domestic guinea pig(100730283) perforin 1 (pore forming protein)
- sheep(101110903) perforin 1 (pore forming protein)
- cow(369025) perforin 1 (pore forming protein)
- Horse(100072744) perforin 1 (pore forming protein)
- domestic cat(100113473) perforin 1 (pore forming protein)
- naked mole-rat(101717851) perforin 1 (pore forming protein)
- dog(489030) perforin 1 (pore forming protein)
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PRF1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Monoclonal Anti-PRF1, (C-terminal) antibody produced in mouse, clone 3B4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-Perforin-1 Antibody, clone 1H11 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human
Application
affinity binding assay
flow cytometry
immunohistochemistry
western blot
flow cytometry
immunohistochemistry
western blot
Perforin (MRQ-23) Mouse Monoclonal Antibody, ,
Species Reactivity
human
Application
immunohistochemistry
Monoclonal Anti-Perforin antibody produced in mouse, clone dG9,
Species Reactivity
bovine, human
Application
flow cytometry