PDCD6IP
programmed cell death 6 interacting protein
Synonyms:
AIP1, ALIX, DRIP4, HP95
Species:
Human PDCD6IP (10015), Mouse Pdcd6ip (18571), Rat Pdcd6ip (501083), naked mole-rat Pdcd6ip (101711093), dog PDCD6IP (477015), chicken PDCD6IP (420725), Zebrafish pdcd6ip (406669), sheep PDCD6IP (101113964), cow PDCD6IP (533406), Horse PDCD6IP (100050741) ...More
UniProtKB ID:
Gene ID:
- Human(10015) Summary: This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012]
- Mouse(18571) programmed cell death 6 interacting protein
- Rat(501083) programmed cell death 6 interacting protein
- naked mole-rat(101711093) programmed cell death 6 interacting protein
- dog(477015) programmed cell death 6 interacting protein
- chicken(420725) programmed cell death 6 interacting protein
- Zebrafish(406669) programmed cell death 6 interacting protein
- sheep(101113964) programmed cell death 6 interacting protein
- cow(533406) programmed cell death 6 interacting protein
- Horse(100050741) programmed cell death 6 interacting protein
- domestic cat(101095279) programmed cell death 6 interacting protein
- domestic guinea pig(100720447) programmed cell death 6 interacting protein
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-AIP1/Alix Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
western blot
western blot
Anti-PDCD6-interacting protein Antibody, clone 12H1.2, clone 12H2.1, from mouse,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Monoclonal Anti-PDCD6IP antibody produced in mouse, clone 3C4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-PDCD6IP antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse
Application
western blot
Anti-PDCD6IP antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot