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Merck

NLRP4

NLR family, pyrin domain containing 4

Synonyms:
CLR19.5, CT58, NALP4, PAN2, PYPAF4, RNH2
Species:
Human NLRP4 (147945), Rat Nlrp4 (499069), domestic cat NLRP4 (101087284), Domestic Rabbit NLRP4 (100349971), Horse NLRP4 (100050883), naked mole-rat Nlrp4 (101719127)
UniProtKB ID:
Q96MN2, Q86W87, Q96AY6
Gene ID:
  • Human(147945) Summary: NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]
  • Rat(499069) NLR family, pyrin domain containing 4
  • domestic cat(101087284) NLR family, pyrin domain containing 4
  • Domestic Rabbit(100349971) NLR family, pyrin domain containing 4
  • Horse(100050883) NLR family, pyrin domain containing 4
  • naked mole-rat(101719127) NLR family, pyrin domain containing 4

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB3500548
Anti-NALP4 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse
Application
ELISA
western blot
HPA062128
Anti-NLRP4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence

esiRNA

Product Number
Description
Species
EHU141341
MISSION® esiRNA, targeting human NLRP4,
Species
human