NARF
nuclear prelamin A recognition factor
Synonyms:
IOP2
Species:
Human NARF (26502), Mouse Narf (67608), Rat Narf (360681), Zebrafish narf (436614), naked mole-rat Narf (101707538), domestic guinea pig Narf (100716616), sheep NARF (101109463), cow NARF (618340), domestic cat NARF (101083050), Horse NARF (100056757) ...More
UniProtKB ID:
Gene ID:
- Human(26502) Summary: Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. [provided by RefSeq, Jul 2008]
- Mouse(67608) nuclear prelamin A recognition factor
- Rat(360681) nuclear prelamin A recognition factor
- Zebrafish(436614) nuclear prelamin A recognition factor
- naked mole-rat(101707538) nuclear prelamin A recognition factor
- domestic guinea pig(100716616) nuclear prelamin A recognition factor
- sheep(101109463) nuclear prelamin A recognition factor
- cow(618340) nuclear prelamin A recognition factor
- domestic cat(101083050) nuclear prelamin A recognition factor
- Horse(100056757) nuclear prelamin A recognition factor
- dog(480819) nuclear prelamin A recognition factor
- chicken(417341) nuclear prelamin A recognition factor
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-NARF antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot
Monoclonal Anti-NARF antibody produced in mouse, clone 7D9, ascites fluid,
Species Reactivity
human
Application
ELISA
western blot
western blot
esiRNA
Product Number
Description
Species