LAMC3
laminin, gamma 3
Synonyms:
OCCM
Species:
Human LAMC3 (10319), Mouse Lamc3 (23928), Rat Lamc3 (311862), domestic guinea pig Lamc3 (100729645), naked mole-rat Lamc3 (101697108), Horse LAMC3 (100069663), cow LAMC3 (518914), dog LAMC3 (491290), Zebrafish lamc3 (558958), chicken LAMC3 (417180) ...More
UniProtKB ID:
Gene ID:
- Human(10319) Summary: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 3. The gamma 3 chain is most similar to the gamma 1 chain, and contains all the 6 domains expected of the gamma chain. It is a component of laminin 12. The gamma 3 chain is broadly expressed in skin, heart, lung, and the reproductive tracts. In skin, it is seen within the basement membrane of the dermal-epidermal junction at points of nerve penetration. Gamma 3 is also a prominent element of the apical surface of ciliated epithelial cells of lung, oviduct, epididymis, ductus deferens, and seminiferous tubules. The distribution of gamma 3-containing laminins along ciliated epithelial surfaces suggests that the apical laminins are important in the morphogenesis and structural stability of the ciliated processes of these cells. [provided by RefSeq, Aug 2011]
- Mouse(23928) laminin gamma 3
- Rat(311862) laminin gamma 3
- domestic guinea pig(100729645) laminin, gamma 3
- naked mole-rat(101697108) laminin, gamma 3
- Horse(100069663) laminin, gamma 3
- cow(518914) laminin, gamma 3
- dog(491290) laminin, gamma 3
- Zebrafish(558958) laminin, gamma 3
- chicken(417180) laminin, gamma 3
- domestic cat(101098499) laminin, gamma 3
- sheep(101122429) laminin, gamma 3
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-LAMC3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-LAMC3 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
immunofluorescence
immunohistochemistry
immunofluorescence
immunohistochemistry