KLKB1
kallikrein B, plasma (Fletcher factor) 1
Synonyms:
KLK3, PPK
Species:
Human KLKB1 (3818), Mouse Klkb1 (16621), Rat Klkb1 (25048), domestic cat KLKB1 (101094092), Horse KLKB1 (100056650), dog KLKB1 (475624), Domestic Rabbit KLKB1 (100356267), sheep KLKB1 (101116376), naked mole-rat Klkb1 (101719264), domestic guinea pig Klkb1 (100715794)
UniProtKB ID:
Gene ID:
- Human(3818) Summary: Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq, Jul 2008]
- Mouse(16621) kallikrein B, plasma 1
- Rat(25048) kallikrein B, plasma 1
- domestic cat(101094092) kallikrein B, plasma (Fletcher factor) 1
- Horse(100056650) kallikrein B, plasma (Fletcher factor) 1
- dog(475624) kallikrein B, plasma (Fletcher factor) 1
- Domestic Rabbit(100356267) kallikrein B, plasma (Fletcher factor) 1
- sheep(101116376) kallikrein B, plasma (Fletcher factor) 1
- naked mole-rat(101719264) kallikrein B, plasma (Fletcher factor) 1
- domestic guinea pig(100715794) kallikrein B, plasma (Fletcher factor) 1
- cow(533547) kallikrein B, plasma (Fletcher factor) 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-KLKB1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, horse, human, rabbit
Application
western blot
esiRNA
Product Number
Description
Species
