HSBP1
heat shock factor binding protein 1
Synonyms:
NPC-A-13
Species:
Human HSBP1 (3281), Mouse Hsbp1 (68196), Rat Hsbp1 (286899), naked mole-rat Hsbp1 (101716916), domestic guinea pig Hsbp1 (100728473), cow HSBP1 (767979), sheep HSBP1 (101122048), dog HSBP1 (609752), chicken HSBP1 (415813)
UniProtKB ID:
Gene ID:
- Human(3281) Summary: The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008]
- Mouse(68196) heat shock factor binding protein 1
- Rat(286899) heat shock factor binding protein 1
- naked mole-rat(101716916) heat shock factor binding protein 1
- domestic guinea pig(100728473) heat shock factor binding protein 1
- cow(767979) heat shock factor binding protein 1
- sheep(101122048) heat shock factor binding protein 1
- dog(609752) heat shock factor binding protein 1
- chicken(415813) heat shock factor binding protein 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-HSBP1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, horse, human, pig, rabbit
Application
western blot