HAAO
3-hydroxyanthranilate 3,4-dioxygenase
Synonyms:
3-HAO, HAO
Species:
Human HAAO (23498), Mouse Haao (107766), Rat Haao (56823), Zebrafish haao (492518), sheep HAAO (101115197), chicken HAAO (421396), dog HAAO (611728), domestic guinea pig Haao (100718413), cow HAAO (510602), domestic cat HAAO (101092928)
UniProtKB ID:
Gene ID:
- Human(23498) Summary: 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008]
- Mouse(107766) 3-hydroxyanthranilate 3,4-dioxygenase
- Rat(56823) 3-hydroxyanthranilate 3,4-dioxygenase
- Zebrafish(492518) 3-hydroxyanthranilate 3,4-dioxygenase
- sheep(101115197) 3-hydroxyanthranilate 3,4-dioxygenase
- chicken(421396) 3-hydroxyanthranilate 3,4-dioxygenase
- dog(611728) 3-hydroxyanthranilate 3,4-dioxygenase
- domestic guinea pig(100718413) 3-hydroxyanthranilate 3,4-dioxygenase
- cow(510602) 3-hydroxyanthranilate 3,4-dioxygenase
- domestic cat(101092928) 3-hydroxyanthranilate 3,4-dioxygenase
- naked mole-rat(101717713) 3-hydroxyanthranilate 3,4-dioxygenase
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-HAAO antibody produced in mouse, clone 4D1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-HAAO antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
Anti-HAAO antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-HAAO antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry