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Merck

GLRB

glycine receptor, beta

Synonyms:
HKPX2
Species:
UniProtKB ID:
Gene ID:
  • Human(2743) Summary: This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
  • Mouse(14658) glycine receptor, beta subunit
  • Rat(25456) glycine receptor, beta
  • naked mole-rat(101709956) glycine receptor, beta
  • dog(475477) glycine receptor, beta
  • Horse(100061981) glycine receptor, beta
  • domestic cat(101088482) glycine receptor, beta
  • cow(281198) glycine receptor, beta
  • sheep(101109484) glycine receptor, beta
  • domestic guinea pig(100727431) glycine receptor, beta
  • chicken(422411) glycine receptor, beta

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Small Molecule - Allosteric Modulator

Product Number
Description
Species
Halothane, United States Pharmacopeia (USP) Reference Standard,
Species
human
Isoflurane, ,
Species
human
2-Bromo-2-chloro-1,1,1-trifluoroethane, ≥99%,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-GLRB antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-Glycine Receptor Antibody, Chemicon®, from rabbit,
Species Reactivity
human, mouse, rat
Application
immunoprecipitation (IP)
western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Glrb,
Species
mouse
MISSION® esiRNA, targeting human GLRB,
Species
human