DMPK
dystrophia myotonica-protein kinase
Synonyms:
DM, DM1, DM1PK, DMK, MDPK, MT-PK
Species:
Human DMPK (1760), Mouse Dmpk (13400), Rat Dmpk (308405), cow DMPK (513675), naked mole-rat Dmpk (101702744), dog DMPK (484436), sheep DMPK (101118379), domestic cat DMPK (101081940), domestic guinea pig Dmpk (100713533)
UniProtKB ID:
Gene ID:
- Human(1760) Summary: The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
- Mouse(13400) dystrophia myotonica-protein kinase
- Rat(308405) dystrophia myotonica-protein kinase
- cow(513675) dystrophia myotonica-protein kinase
- naked mole-rat(101702744) dystrophia myotonica-protein kinase
- dog(484436) dystrophia myotonica-protein kinase
- sheep(101118379) dystrophia myotonica-protein kinase
- domestic cat(101081940) dystrophia myotonica-protein kinase
- domestic guinea pig(100713533) dystrophia myotonica-protein kinase
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-DMPK antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-DMPK antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Proteins
Product Number
Description
Species
DMPK, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
DMPK Protein, active, 10 µg, Active, 6His-tagged, recombinant, human DMPK, amino acids 1-549, for use in Kinase Assays.,
Species
human