CTCF
CCCTC-binding factor (zinc finger protein)
Synonyms:
Species:
Human CTCF (10664), Mouse Ctcf (13018), Rat Ctcf (83726), domestic guinea pig Ctcf (100732580), Domestic Rabbit CTCF (100350641), chicken CTCF (396274), naked mole-rat Ctcf (101709585), Zebrafish ctcf (415104), domestic cat CTCF (101101354), sheep CTCF (101114297) ...More
UniProtKB ID:
Gene ID:
- Human(10664) Summary: This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
- Mouse(13018) CCCTC-binding factor
- Rat(83726) CCCTC-binding factor (zinc finger protein)
- domestic guinea pig(100732580) CCCTC-binding factor (zinc finger protein)
- Domestic Rabbit(100350641) CCCTC-binding factor (zinc finger protein)
- chicken(396274) CCCTC-binding factor (zinc finger protein)
- naked mole-rat(101709585) CCCTC-binding factor (zinc finger protein)
- Zebrafish(415104) CCCTC-binding factor (zinc finger protein)
- domestic cat(101101354) CCCTC-binding factor (zinc finger protein)
- sheep(101114297) CCCTC-binding factor (zinc finger protein)
- cow(517097) CCCTC-binding factor (zinc finger protein)
- Horse(100053363) CCCTC-binding factor (zinc finger protein)
- dog(479684) CCCTC-binding factor (zinc finger protein)
- fruit fly(38817) CG8591 gene product from transcript CG8591-RA
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-CTCF Antibody, serum, Upstate®,
Species Reactivity
canine, human, mouse, primate, rat
Application
ChIP
western blot
western blot
Monoclonal Anti-CTCF antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL0304, purified immunoglobulin, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-CTCF antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
ChIPAb+ CTCF - ChIP Validated Antibody and Primer Set, clone 1.2.1.5.4, from mouse,
Species Reactivity
human
Application
ChIP
ELISA
dot blot
immunohistochemistry
immunoprecipitation (IP)
multiplexing
western blot
ELISA
dot blot
immunohistochemistry
immunoprecipitation (IP)
multiplexing
western blot
Anti-CTCF antibody, clone 1B18, ZooMAb® Rabbit monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot