Z701076

Human Embryonic Stem Cells: An Introduction to the Science and Therapeutic Potential

• ISBN-10: 0-7637-2341-X
• ISBN-13: 978-0-7637-2341-5
• UNSPSC Code: 55101509

Properties

• publication info: A. Kiessling and S. Anderson, Jones and Bartlett, 2003, 230 pp., soft cover

Description

General description

The social debate involving the creation of human embryos for stem cell therapy prompted the writing of this text. The emerging field of human embryonic stem cell biomedicine crosses many disciplinary boundaries - cell biology, reproductive biology, embryology, molecular biology, endocrinology, immunology, fetal medicine, transplantation medicine and surgery. This single reference provides basic information from these multiple disciplines as it pertains to the science of stem cells.

Table of Contents

Part I - The Basics
Chapter 1 - The Nature of Stem Cells
Adult Stem Cells
Fetal Tissue Stem Cells
Sidebar: Bone Marrow Transplantation: E. Donnell Thomas
Embryonic Stem Cells
Nuclear Transfer Stem Cells
Human Cloning
Chapter 2 The Dividing Cell
The Cell Cycle
Stimulating Cell Division
Molecular Biology of the Cell Cycle
Sidebar: Cell Cycle Regulators: Lee Hartwell, Paul Nurse, and Tim Hunt
Part II - Egg Specific Functions
Chapter 3 - The Egg
Egg Growth
Oocyte Meiosis
Assisted Reproductive Technologies
Molecular Biology of Oocyte Meiosis
Sidebar: cMos Activiity: Metaphase II Arrest
Chapter 4 - The Activated Egg
Spontaneous Egg Activation
Artificial Egg Activation
Egg Activation by Sperm
Sidebar: Activation of Human Eggs: In Vitro Fertilization and
Cleavage of Human Ovarian Eggs
Egg Activation Following Nuclear Transplantation
Molecular Biology of Egg Activation
Chapter 5 - The Zygote
The Pronuclear Stage Egg
Manipulation of the Zygote
Parthenotes
Haploid Parthenotes
Sidebar: Transgenic Mice: Introduction of Foreign
Genes in Zygotes
Diploid Parthenotes
Molecular Biology of Zygotes
Chapter 6 - Blastomere Cleavage
The First Cleavage
The Second Cleavage
Fragmented Cleavages
The Third, Fourth, and Fifth Cleavages
Embryo Development in Laboratory Conditions
Sidebar: Development of Tissue Culture Media
Molecular Biology of Blastomere Cleavage
Chapter 7 - Basic Nuclear Transfer Technology
Transfer of Nuclei into Frog Eggs
Sidebar: Development Potential of Transplanted Nuclei
Gene Expression: Transcription and Translation
Transcription and Translation in Frog Eggs
Reprogramming a Nucleus
Part III - Embryonic Stem Cells
Chapter 8 - The Blastocyst and Inner Cell Mass Cells
Equivalence Groups
The Blastocyst
Primitive Endoderm
Implantation
Blastocyst Development In Vitro
Embryonic Stem Cells
Chimeras
Sidebar: Knockout Mice
Chapter 9 - Organogenesis
The Second Week
The Third Week
The Fourth Week
Fifth and Sixth Weeks
Primordial Germ Cell Migration
Fetal Tissue Stem Cells
Sidebar: Primordial Germ Cells and Embryonal
Carcinoma Cells
Chapter 10 - Mammalian Nuclear Transfer Technologies
Transplantation of Embryonic Nuclei into Fertilized Eggs
Nuclear Transplantation and the Cell Cycle of Fertilized Eggs
Transplantation of Embryonic Nuclei into Unfertilized Eggs
Transplantation of Somatic Cell Nuclei into Unfertilized Eggs
Animal Cloning
Challenges in Human Therapeutic Cloning
Sidebar: Somatic Cell Nuclear Transfer in Humans: Pronuclear
Early Embryonic Development
Chapter 11 - Stem Cell Differentiation
Adult Stem Cells
Fetal Stem Cells
Human Embryonic Stem Cells
Human Parthenote Stem Cells
Part IV - Stem Cell Therapies
Chapter 12 - Neurogenerative Diseases
Parkinson′s Disease
Alzheimer′s
Other Brain Syndromes
Spinal Cord Injury
Chapter 13 - Tissue Systems Failures
Diabetes
Type 1 Diabetes
Type 2 Diabetes
Cardiomyopathy
Kidney Failure
Liver Failure
Cancer
Hemophilia
Part V - Human Embryonic Stem Cells and Society
Chapter 14 - The Religious, Legal, Ethical, and Scientific Debate
The Religious Debate
The Legal Debate
The Ethical Debate
The Scientific Debate
The Future of the Debate
Glossary
Index