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T1512

Sigma-Aldrich

Tetramisole hydrochloride

powder, ≥99% (TLC)

Synonym(s):

(±)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C11H12N2S · HCl
CAS Number:
5086-74-8
Molecular Weight:
240.75
Beilstein/REAXYS Number:
4358989
EC Number:
225-799-5
MDL number:
MFCD00005536
UNSPSC Code:
12352202
PubChem Substance ID:
24278725
NACRES:
NA.77

product name

Tetramisole hydrochloride, phosphatase inhibitor

biological source

synthetic (organic)

Quality Level

200

description

alkaline phosphatase inhibitor

assay

≥99% (TLC)

form

powder

mp

266-267 °C (lit.)

solubility

water: 50 mg/mL, clear, colorless

SMILES string

Cl[H].C1CN2CC(N=C2S1)c3ccccc3

InChI

1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H

InChI key

LAZPBGZRMVRFKY-UHFFFAOYSA-N

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Application

Structure-activity relationship for tetramisole derivatives as alkaline phosphatase inhibitors.
Suitable for inhibition of various mammalian alkaline phosphatases (i.e., liver, kidney, placenta, bone and tumor). Intestinal alkaline phosphatases are only slightly inhibited.

Other Notes

Racemic form of levamisole.

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Description
Pricing

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Oocytes are large cells that develop into an embryo upon fertilization1. As interconnected germ cells mature into oocytes, some of them grow-typically at the expense of others that undergo cell death2-4. We present evidence that in the nematode Caenorhabditis elegans
Kinetics and inhibition of alkaline phosphatases from canine tissues.
H Van Belle
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