SML0330

S3I-201

≥97% (HPLC)

• Synonym(s): 2-Hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid, NSC 74859
• Empirical Formula (Hill Notation): C₁₆H₁₅NO₇S
• CAS Number: 501919-59-1
• Molecular Weight: 365.36
• MDL number: MFCD09907564
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825335
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥97% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: >10 mg/mL
• storage temp.: −20°C
• SMILES string: Cc1ccc(cc1)S(=O)(=O)OCC(=O)Nc2ccc(C(O)=O)c(O)c2
• InChI: 1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)
• InChI key: HWNUSGNZBAISFM-UHFFFAOYSA-N

Description

Application

S3I-201 has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor:

• to confirm the role of STAT3 phosphorylation in interleukin (IL)-33 production in lung epithelial cells and IL-22 mRNA expression in sorted group 3 innate lymphoid cells (ILC3s)
• to study the cellular response of STAT3 triggered by β-hexaclorocyclohexane (β-HCH) in various cell lines
• to examine the influence of STAT3 in response to angiotensin II (ang II) on induction of fibrotic proteins in kidney epithelial cells

Biochem/physiol Actions

Inhibition of signal transducer and activator of transcription 3 (STAT3) activity by S3I-201 may be a potential therapeutic strategy for hypertensive kidney disease.

S3I-201 is a cell-permeable Stat3 inhibitor that binds to the Stat3-SH2 domain, prevents Stat3 phosphorylation/activation, dimerization, and DNA-binding.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable