The suitability of this compound for use in FACS has not been determined. This application would need to be validated by the end user. Please see the link below to a publication that may be helpful:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718257/
Q3251
Quinacrine dihydrochloride
≥90% (TLC), powder, MAO-A/B inhibitor
Synonym(s):
6-Chloro-9-(4-diethylamino-1-methylbutylamino)-2-methoxyacridine dihydrochloride, Atebrin dihydrochloride, Mepacrine dihydrochloride
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25 G
$150.00
100 G
$486.00
About This Item
Empirical Formula (Hill Notation):
C23H30ClN3O · 2HCl
CAS Number:
Molecular Weight:
472.88
Beilstein/REAXYS Number:
4834013
EC Number:
MDL number:
UNSPSC Code:
12352101
PubChem Substance ID:
NACRES:
NA.77
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Product Name
Quinacrine dihydrochloride, ≥90%
biological source
synthetic
Quality Level
assay
≥90%
form
powder
mp
257 °C
solubility
H2O: soluble, clear to hazy
originator
Bayer
SMILES string
Cl[H].Cl[H].CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc3ccc(OC)cc13
InChI
1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H
InChI key
UDKVBVICMUEIKS-UHFFFAOYSA-N
Gene Information
human ... MAOA(4128) , MAOB(4129)
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General description
Quinacrine is an acridine derivative and a potent antimalarial agent.[1]
Application
Biochem/physiol Actions
Non-selective MAO-A/B inhibitor.
Quinacrine has anthelmintic functionality and used in the female sterilization. It is used to treat systemic lupus erythematosus and rheumatic diseases.[1] Apart from malaria, Quinacrine is effective for treating giardia and tapeworm infections.[5] It inhibits nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity in addition to monoamine oxidase inhibition.[6]
Features and Benefits
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage and Stability
Stock solutions are stable for up to 60 h at 20°C.
Other Notes
This product is not assigned an expiration date or recommended retest date.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Is it okay to measure fluorescence by using FACS? (with FITC Fluorochrome)
1 answer-
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How long can it be used after purchasing?
1 answer-
This product is not assigned an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one-year warranty from the date of shipment. For more information, you may access the Product Dating Information document under ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management/quality-services.
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I’m planning to make stocks for 10mM. What is the storage temperature? Is it same with the product?
1 answer-
Stock solutions are stable for up to 60 h at 20°C.
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What is the storage temperature?
1 answer-
Product Q3251, Quinacrine dihydrochloride, is stored at room temperature.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Can Product Q3251, Quinacrine dihydrochloride be used for staining platelets?
1 answer-
We have not tested Product Q3251, Quinacrine dihydrochloride for staining platelets. The reference link indicates that platelets can be visualized with the fluorescent dye mepacrine (quinacrine dihydrochloride) at a final concentration of 10 μM. Brian Savage, et al., PNAS, 99 (1): 425-430, (2002).
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