P9716

Palmitoyl coenzyme A lithium salt

≥90%

• Synonym(s): n-Hexadecanoyl Coenzyme A, Hexadecanoyl coenzyme A
• Empirical Formula (Hill Notation): C₃₇H₆₅N₇O₁₇P₃S · xLi⁺
• CAS Number: 188174-64-3
• Molecular Weight: 1004.94 (free acid basis)
• MDL number: MFCD01863103
• UNSPSC Code: 51111800
• PubChem Substance ID: 24899057
• NACRES: NA.77

Properties

• Quality Level: 200
• assay: ≥90%
• form: powder
• storage temp.: −20°C
• SMILES string: [Li+].CCCCCCCCCCCCCCCC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23
• InChI: 1S/C37H66N7O17P3S.Li/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44;/h24-26,30-32,36,47-48H,4-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52);/q;+1/p-1/t26-,30-,31-,32+,36-;/m1./s1
• InChI key: BSAYABVAJQBKKB-NNGKVBCISA-M

Description

Application

Palmitoyl coenzyme A lithium salt has been used for microinjecting newt egg, to study the effect of citrate synthase inhibition in egg activation.[1] It has also been used in reaction mix for thioesterase I (tesA) enzymatic activity assay.[2]Palmitoyl coenzyme A lithium salt has been used in in vitro S-palmitoylation of cyclophilin D.[3]

Biochem/physiol Actions

Palmitoyl coenzyme A (CoA) is an acyl-CoA and a precursor of 3-ketodihydrosphingosine, a key element of sphingoid base backbone[4] during the De novo sphingolipid biosynthesis.[5] Palmitoyl CoA is a long chain fatty acid (C16) covalently linked to Coenzyme A. Covalent attachment of palmitate is a common occurrence on a wide variety of viral and cellular proteins and plays a role in promoting membrane binding. Palmitoylation may also be a general mechanism for prolonging or potentiating G-protein signaling.

Palmitoyl coenzyme A is useful in the biosynthesis of sphingosine,[6] a component of sphingolipids and phospholipids.[7]β-Oxidation of Palmitoyl-CoA yields 8 acetyl-CoA molecules and 14 pairs of hydrogen atoms.[8]

Features and Benefits

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Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)