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O9637

Sigma-Aldrich

Oxaprozin

solid

Synonym(s):

4,5-Diphenyl-2-oxazolepropanoic acid, Daypro

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About This Item

Empirical Formula (Hill Notation):
C18H15NO3
CAS Number:
21256-18-8
Molecular Weight:
293.32
EC Number:
244-296-1
MDL number:
MFCD00215977
UNSPSC Code:
12352200
PubChem Substance ID:
24278617
NACRES:
NA.77

form

solid

Quality Level

200

SMILES string

OC(=O)CCc1nc(-c2ccccc2)c(o1)-c3ccccc3

InChI

1S/C18H15NO3/c20-16(21)12-11-15-19-17(13-7-3-1-4-8-13)18(22-15)14-9-5-2-6-10-14/h1-10H,11-12H2,(H,20,21)

InChI key

OFPXSFXSNFPTHF-UHFFFAOYSA-N

Gene Information

human ... PTGIR(5739) , PTGS1(5742) , PTGS2(5743)

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General description

Oxaprozin is a non-steroidal anti-inflammatory drug prescribed for rheumatoid arthritis (RA) and osteoarthritis (OA). Oxaprozin binds to albumin. It inhibits arachidonic acid pathway. Oxaprozin has anti-inflammatory property and is an effective inhibitor of cyclooxygenase enzymes, COX-1 and COX-2.

Application

Anti-inflammatory

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Shao-Fa Sun et al.
International journal of biological macromolecules, 39(4-5), 197-200 (2006-07-11)
The interaction between Oxaprozin-E and bovine serum albumin (BSA) was studied by spectroscopic methods including fluorescence and UV-vis absorption spectroscopy. The quenching mechanism of fluorescence of BSA by Oxaprozin-E was discussed to be a dynamic quenching procedure. The number of
Recent pharmacodynamic and pharmacokinetic findings on oxaprozin
Rainsford KD, et al.
Inflammopharmacology, 10(3), 185-239 (2002)
Isa M Kara et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 68(5), 1018-1024 (2010-03-09)
In this study, oxaprozin, a long-acting nonsteroidal anti-inflammatory drug, and naproxen sodium were compared in terms of their effects on edema, pain, and trismus after surgery for impacted mandibular third molars. Thirty healthy patients with bilaterally impacted mandibular third molars
Allen Brinker et al.
Drugs & aging, 21(7), 479-484 (2004-05-11)
Data on file with the US FDA, and other published studies, suggest that the selective cyclo-oxygenase (COX)-2 inhibitor NSAID rofecoxib has a greater hypertensive adverse effect than other NSAIDs, including celecoxib. In this study we describe a pharmacoepidemiologic analysis of
Zhidong Liu et al.
The Journal of pharmacy and pharmacology, 58(1), 45-50 (2006-01-06)
Our purpose was to explore the use of Transcutol P (Trans) in an ocular drug delivery system. The effect of Trans on the corneal permeability of drugs was investigated in-vitro, using isolated rabbit corneas. The ocular irritation of Trans was
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