M5319
Matrine
Synonym(s):
Matridin-15-one, Sophocarpidine
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All Photos(3)
About This Item
Empirical Formula (Hill Notation):
C15H24N2O
CAS Number:
Molecular Weight:
248.36
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.25
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Quality Level
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
SMILES string
O=C1CCCC2C3CCCN4CCCC(CN12)C34
InChI
1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1
InChI key
ZSBXGIUJOOQZMP-JLNYLFASSA-N
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General description
Matrine (MT) or Sophocarpidine is a naturally occurring bioactive compound, extracted from traditional Chinese herbs like Sophora flavescens and Radix Sophorae tonkinensis.[1]
Application
Matrine has been used:
- to study its antioxidant and protective effect on doxorubicin (DOX)-induced cardiotoxicity in mice model and H9C2 cells[2]
- as a chemotherapeutic agent to test its inhibitory effect on the growth of human glioblastoma multiforme (GBM) cells[3], and ovarian cancer cells[4]
- to study its effect on mitochondrial fission and its anti-tumor functionality in HepG2 cells[5]
- as a necroptosis inducer in cholangiocarcinoma (CCA) cell lines[6]
Biochem/physiol Actions
Matrine is a potent therapeutic agent with various pharmacological like anti-cancer, anti-bacterial, anti-fibrotic, anti-inflammatory properties.[1] It is a macropinocytosis inducer and decreases the cellular adenosine triphosphate (ATP) level.[7] Matrine may also serve as an effective sedative agent.[8] It serves as an anti-inflammatory agent in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced intestinal inflammation in mice.[9] It functions to reverse the Warburg effect and suppress the growth of human colon cancer cells.[10]
Matrine is an alkaloid that is one of the major components in the root of the saphoro plant. Matrine has been studied for possible antiviral efficacy against hepatitis B and C, as well as impact against some skin diseases and forms of cancer.
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Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Peiyuan Li et al.
Frontiers in physiology, 10, 28-28 (2019-02-26)
This study mainly investigated the effect of matrine on TNBS-induced intestinal inflammation in mice. TNBS treatment caused colonic injury and gut inflammation. Matrine (1, 5, and 10 mg/kg) treatment alleviated colonic injury and gut inflammation via reducing bleeding and diarrhea
Arsenic trioxide-induced hERG K(+) channel deficiency can be rescued by matrine and oxymatrine through up-regulating transcription factor Sp1 expression.
Zhang Y, Dong Z, Jin L, et al.
Biochemical Pharmacology (2012)
Wenjing Zhou et al.
Cancer medicine, 7(9), 4729-4743 (2018-08-07)
Matrine, a traditional Chinese medicine, has recently been shown to have antitumor properties in diverse cancer cells. Here, we explored the effect of matrine on human glioblastoma multiforme (GBM) cells. Glioblastoma multiforme cell lines were treated with matrine to assess
Hyun-Ju Lee et al.
Biomolecules & therapeutics, 25(4), 390-395 (2017-02-14)
The present study investigated the sedative effects of Sophora flavescens (SF) and its bioactive compound, matrine through performing locomotor activity test and the electroencephalography (EEG) analysis in the rat. The underlying neural mechanism of their beneficial effects was determined by
Can Hu et al.
Acta pharmaceutica Sinica. B, 9(4), 690-701 (2019-08-07)
Oxidative stress and cardiomyocyte apoptosis are involved in the pathogenesis of doxorubicin (DOX)-induced cardiotoxicity. Matrine is well-known for its powerful anti-oxidant and anti-apoptotic capacities. Our present study aimed to investigate the effect of matrine on DOX-induced cardiotoxicity and try to
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