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MilliporeSigma

L7022

Sigma-Aldrich

Sodium L-lactate

~98%

Synonym(s):

(S)-2-Hydroxypropionic acid sodium salt, L-Lactic acid sodium salt, Sarcolactic acid sodium salt

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About This Item

Empirical Formula (Hill Notation):
C3H5NaO3
CAS Number:
Molecular Weight:
112.06
Beilstein/REAXYS Number:
4567087
EC Number:
MDL number:
UNSPSC Code:
12352201
PubChem Substance ID:
NACRES:
NA.25

Pricing and availability is not currently available.

biological source

synthetic (chemical)

Quality Level

assay

~98%

form

powder or crystals

color

white to faint yellow

mp

163-165 °C (lit.)

solubility

water: 50 mg/mL, clear, colorless

storage temp.

2-8°C

SMILES string

[Na+].C[C@H](O)C([O-])=O

InChI

1S/C3H6O3.Na/c1-2(4)3(5)6;/h2,4H,1H3,(H,5,6);/q;+1/p-1/t2-;/m0./s1

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1 of 4

This Item
H11602253189106615
Quality Level

100

Quality Level

200

Quality Level

-

Quality Level

-

mp

7 °C (lit.)

mp

7 °C (lit.)

mp

-

mp

189-191 °C (lit.)

bp

230-232 °C/740 mmHg (lit.)

bp

230-232 °C/740 mmHg (lit.)

bp

80-90 °C/10 mmHg (lit.)

bp

-

form

liquid

form

-

form

liquid

form

solid

density

1.03 g/mL at 25 °C (lit.)

density

1.03 g/mL at 25 °C (lit.)

density

0.903 g/mL at 25 °C (lit.)

density

-

General description

Sodium L-lactate, an organic acid derived from L-lactic acid, naturally occurs in the body, contributing to pH regulation, acid-base equilibrium, and various physiological processes, including energy metabolism through the Cori cycle. Its versatile properties extend to antimicrobial action by creating an acidic environment that inhibits harmful bacterial growth. In metabolic pathways, Sodium L-lactate exhibits efficient conversion for energy production, potentially surpassing glucose uptake in certain instances, utilizing fatty acids as an alternative fuel source, and stimulating mitochondria for enhanced ATP production, indicating a role in optimizing cellular energy efficiency. Moreover, research suggests neuroprotective capabilities, safeguarding neuronal cells from high-fat diet-induced death and addressing potential links to obesity-related neurodegenerative issues.

This multifaceted nature of Sodium L-lactate positions it as a valuable molecule for research in cellular metabolism, neuroprotection, antimicrobial, and nutritional science, where its diverse properties, including efficient energy conversion, neuroprotective effects, and potent antimicrobial activity contribute to a deeper understanding across these scientific domains.

Application

Sodium L-lactate has been used:
  • as a medium supplement and cell fuel source for human mammary epithelial cell line(MCF10A)[1] and dendritic cell culture[2]
  • as a gluconeogenic substrate in hepatic glucose production assay in primary hepatocytes[3]
  • in the glucose production medium for glucose production assay in human embryonic kidney (HEK293T) cells[4]
  • as a standard for calibration in lactate assay in bone marrow-derived macrophages[5]

Biochem/physiol Actions

L-lactate is produced from pyruvate by the enzyme lactate dehydrogenase. Lactate production occurs during anaerobic glycolysis or in proliferatively active cells.[6]

Features and Benefits

Versatile and adaptable for a wide variety of laboratory and research applications

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificates of Analysis (COA)

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This is a sample Certificate of Analysis (COA) and may not represent a recently manufactured lot of this specific product.

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Etomoxir inhibits macrophage polarization by disrupting CoA homeostasis
Divakaruni AS, et al.
Cell Metabolism, 28(3), 490-503 (2018)
Latent, Immunosuppressive Nature of Poly (lactic-co-glycolic acid) Microparticles
Allen RP, et al.
ACS biomaterials science & engineering, 4(3), 900-918 (2018)
Dynamic acetylation of phosphoenolpyruvate carboxykinase toggles enzyme activity between gluconeogenic and anaplerotic reactions
Latorre-Muro P, et al.
Molecular Cell, 71(5), 718-732 (2018)
Protein-bound NAD (P) H Lifetime is Sensitive to Multiple Fates of Glucose Carbon
Sharick JT, et al.
Scientific Reports, 8(1), 5456-5456 (2018)
Alternative splicing variant of the scaffold protein APPL1 suppresses hepatic adiponectin signaling and function
Galan-Davila AK, et al.
The Journal of Biological Chemistry, jbc-RA118 (2018)

Articles

Sigma article discusses tumor cell metabolic pathways, focusing on aerobic glycolysis and mitochondrial activity.

Warburg effect enhances glucose to lactate conversion in tumor cells, regardless of oxygen levels; impacting cancer metabolism since 1924.

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