H6515
L-Homoserine
Synonym(s):
(S)-2-Amino-4-hydroxybutyric acid, Hse
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5 G
$1,770.00
About This Item
Linear Formula:
HOCH2CH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
119.12
Beilstein/REAXYS Number:
1721681
EC Number:
MDL number:
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26
Recommended Products
assay
≥98% (TLC)
Quality Level
form
powder
color
white to off-white
mp
203 °C (dec.) (lit.)
application(s)
cell analysis
detection
SMILES string
N[C@@H](CCO)C(O)=O
InChI
1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1
InChI key
UKAUYVFTDYCKQA-VKHMYHEASA-N
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General description
L-Homoserine is a variant of serine with an additional carbon on its side chain.[1]
Application
Biochem/physiol Actions
L-Homoserine is synthesized by deoxidation process, catalysed by homoserine dehydrogenase. This is one of the steps in the synthesis of L-threonine. The carbon flux in in bacteria such as E. coli is maintained by this reaction.[4]
L-Homoserine is used in the biosynthesis of methionine, threonine and isoleucine.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Minsang Lee et al.
The Plant journal : for cell and molecular biology, 41(5), 685-696 (2005-02-11)
Homoserine kinase (HSK) produces O-phospho-l-homoserine (HserP) used by cystathionine gamma-synthase (CGS) for Met synthesis and threonine synthase (TS) for Thr synthesis. The effects of overexpressing Arabidopsis thaliana HSK, CGS, and Escherichia coli TS (eTS), each controlled by the 35S promoter
Neurotoxic effect of maneb in rats as studied by neurochemical and immunohistochemical parameters
Nielsen BS, et al.
Environmental Toxicology and Pharmacology, 21(3), 268-275 (2006)
Reprogramming Microbial Metabolic Pathways, 288-288 (2012)
Chiral recognition of non-natural ?-amino acids
Gal JF, et al.
International Journal of Mass Spectrometry, 222(1?3), 259-267 (2003)
D C Turnell et al.
Clinical chemistry, 28(3), 527-531 (1982-03-01)
This method for estimating clinically important amino acids in serum or urine within 40 min involves o-phthalaldehyde/2-mercaptoethanol derivatization and reversed-phase "high-pressure" liquid chromatography. Homocysteic acid is an internal standard, and homoserine and norvaline are reference peaks. For all the amino
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