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Key Documents

H1254

Sigma-Aldrich

8-Hydroxyquinoline glucuronide

≥95%, powder

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About This Item

Empirical Formula (Hill Notation):
C15H15NO7
CAS Number:
Molecular Weight:
321.28
EC Number:
MDL number:
UNSPSC Code:
12352204
PubChem Substance ID:

assay

≥95%

form

powder

color

light green

SMILES string

O[C@@H]1[C@H](O[C@H]([C@H](O)[C@H]1O)C(O)=O)Oc2cccc3cccnc23

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Substrates

Substrate for the histochemical demonstration of β-glucuronidase and for quantitative assay systems.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Andrew D Pris et al.
Analytical chemistry, 81(24), 9948-9954 (2009-11-18)
Enabling trace chemical detection equipment utilized in the field to transduce a biodetection assay would be advantageous from a logistics, training, and maintenance standpoint. Described herein is an assay design that uses an unmodified, commercial off-the-shelf (COTS) ion trap mobility
T P Monson et al.
International journal of radiation oncology, biology, physics, 20(6), 1263-1271 (1991-06-01)
RIF-1 mouse tumors express high levels of beta-glucuronidase activity relative to most normal tissues. The high activity can be exploited for targeting specific drugs preferentially to tumor tissues. In this study we examined the kinetics of 8-hydroxyquinoline (8-OHQ) accumulation in
Peter Tobin et al.
British journal of clinical pharmacology, 62(1), 122-129 (2006-07-18)
Irinotecan (CPT-11) is a prodrug that is used to treat metastatic colorectal cancer. It is activated to the topoisomerase poison SN-38 by carboxylesterases. SN-38 is metabolized to its inactive glucuronide, SN-38 glucuronide. The aim of this study was to determine
T Unak et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 48(6), 777-783 (1997-06-01)
Some types of cancer cells have high levels of beta-glucuronidase activity. This enzyme is able to deglucuronidate a variety of glucuronide derivatives on the cell membrane. Either O- or N-glucuronides can be selectively incorporated into the cancer cells. If the
Takahisa Sakaguchi et al.
Journal of pharmaceutical and biomedical analysis, 40(2), 345-352 (2005-08-30)
An on-line purification method for cationic compounds and their metabolites in rat bile was investigated using a column-switching technique. 8-Hydroxyquinoline and its glucuronide were used as test compounds. Bile samples were injected directly into the system and successful on-line extraction

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