Elucidating uptake and metabolic fate of dipeptides in CHO cell cultures using (13)C labeling experiments and kinetic modeling: This study delves into the uptake and metabolic processing of dipeptides such as Gly-Tyr in cell cultures, providing insights into their utilization and role in enhancing biopharmaceutical production processes (Naik et al., 2024).
Tyrosine may be a conditionally indispensable amino acid in the neonate; however, the provision of aromatic amino acids to neonates receiving total parenteral nutrition (TPN) is complicated by the poor solubility of crystalline tyrosine. In the present study, we investigated
The biological activities of proteins depend on specific molecular recognition and binding. Computational methods for predicting binding modes can facilitate the discovery and design of ligands and yield information on the factors governing complementarity. The DOCK suite of programs has
Clinical science (London, England : 1979), 76(6), 643-648 (1989-06-01)
1. A commercial amino acid solution supplemented with two synthetic dipeptides, L-alanyl-L-glutamine (Ala-Gln) and glycyl-L-tyrosine (Gly-Tyr), or alternatively with isonitrogenous amounts of free alanine and glycine has been continuously infused over 4 h in six apparently healthy volunteers. 2. The
The Journal of nutrition, 126(3), 663-667 (1996-03-01)
Poor solubility hampers the addition of sufficient amounts of free tyrosine to parenteral amino solutions. We investigated the use of a highly soluble synthetic dipeptide, glycyl-L-tyrosine, as a parenteral tyrosine source in 18 male Wistar rats (body weight 180-200 g).
The American journal of physiology, 267(5 Pt 1), E672-E679 (1994-11-01)
Low tyrosine solubility in total parenteral nutrition (TPN) solutions complicates meeting the aromatic amino acid needs of infants. This study compared the effectiveness of two tyrosine precursors to supply the aromatic amino acid needs of TPN-fed neonatal piglets with a
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