G117

Glipizide

solid

• Synonym(s): 1-Cyclohexyl-3-{4-[2-(5-methylpyrazine-2-carboxamido)ethyl]phenylsulfonyl}urea
• Empirical Formula (Hill Notation): C₂₁H₂₇N₅O₄S
• CAS Number: 29094-61-9
• Molecular Weight: 445.54
• EC Number: 249-427-6
• MDL number: MFCD00072159
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277839
• NACRES: NA.77

Properties

• form: solid
• Quality Level: 100
• color: white
• solubility: methanol: 1.9 mg/mL; DMSO: 48 mg/mL
• SMILES string: Cc1cnc(cn1)C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3
• InChI: 1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28)
• InChI key: ZJJXGWJIGJFDTL-UHFFFAOYSA-N
• Gene Information: human ... ABCC8(6833) , KCNJ1(3758) , KCNJ11(3767)

Description

General description

Potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1) codes for a renal outer medullary potassium channel (ROMK1, Kir1.1).[1] Glipizide is an antidiabetic drug, that is used to treat type II diabetes.(5)

Application

Glipizide has been used in:

• chick embryo yolk sac membrane (YSM) and chorioallantoic membrane (CAM) assay[2]
• MCF-7 breast cancer assay on chorioallantoic membrane (CAM)[2]
• metastasis assays[2][3]
• rat aortic ring assay[3]
• in vivo matrigel plug assay
• 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay[3]
• flow cytometry[3]
• western blotting[3]

Biochem/physiol Actions

Potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1) plays a vital role in potassium balance.[4] It is an ATP-dependent K⁺ channel blocker. The encoded protein is liable for the elimination of potassium in exchange for the absorption of sodium by the epithelial sodium channel (ENaC).[1] Mutation in KCNJ1 is linked with several diseases, such as, antenatal Bartter syndrome and diabetes.[4] Glipizide helps to repress the development of tumors and metastasis by preventing angiogenesis.[2]

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)