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D1069

Desloratadine

≥98% (HPLC), histamine H1 receptor antagonist, powder

Synonym(s):

8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H- benzo[5,6]cyclohepta[1,2,b]pyridine, Clarinex®, NSC 675447

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$233.00

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$828.00

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About This Item

Empirical Formula (Hill Notation):
C19H19ClN2
CAS Number:
100643-71-8
Molecular Weight:
310.82
UNSPSC Code:
12352200
PubChem Substance ID:
329798668
NACRES:
NA.32
MDL number:
MFCD00871949

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Product Name

Desloratadine, powder, ≥98% (HPLC)

SMILES string

Clc1ccc2c(CCc3cccnc3\C2=C4\CCNCC4)c1

InChI key

JAUOIFJMECXRGI-UHFFFAOYSA-N

InChI

1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2

assay

≥98% (HPLC)

form

powder

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... HRH1(3269)

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1 of 4

This Item
PHR16801173042Y0001584
Desloratadine powder, ≥98% (HPLC)

Sigma-Aldrich

D1069

Desloratadine

Desloratidine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1680

Desloratidine

Desloratadine United States Pharmacopeia (USP) Reference Standard

USP

1173042

Desloratadine

Desloratadine European Pharmacopoeia (EP) Reference Standard

Y0001584

Desloratadine

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

Quality Level

100

Quality Level

300

Quality Level

-

Quality Level

-

form

powder

form

-

form

-

form

-

storage temp.

2-8°C

storage temp.

2-30°C

storage temp.

-

storage temp.

2-8°C

Gene Information

human ... HRH1(3269)

Gene Information

human ... HRH1(3269)

Gene Information

human ... HRH1(3269)

Gene Information

human ... HRH1(3269)

solubility

DMSO: >10 mg/mL

solubility

-

solubility

-

solubility

-

Application

Desloratadine has been used to test its effect on embryoid body development in in vitro gastrulation model of P19C5 stem cells.[1] It has also been used as an antihistamine mimic in rats[2] and to treat lung cancer (A549) and glioblastoma (U87) cells in various cellular studies.[3]

Biochem/physiol Actions

A non-sedating H1-receptor antagonist, free from antimuscarinic/anticholinergic effects. It has novel antiallergic and anti-inflammatory effects.
Desloratadine is a selective and nonsedating histamine H1 receptor antagonist, an active metabolite of loratadine (Claritin), used to relieve hay fever and allergy symptoms with less drowsiness than other antihistamines; does not significantly inhibits cardiac K+ channels at clinically achievable blood levels. Free from antimuscarinic/anticholinergic effects.

Legal Information

Clarinex is a registered trademark of Schering Corp.

related product

Product No.
Description
Pricing

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

390.2 °F - Pensky-Martens closed cup

flash_point_c

199 °C - Pensky-Martens closed cup

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Certificates of Analysis (COA)

Lot/Batch Number
0000396280
0000396280
0000263326
0000235913
0000235913

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Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels
Villalpando-Rodriguez GE, et al.
Oxidative Medicine and Cellular Longevity, 2019 (2019)
Translational Physiology: Prolonged intake of desloratadine: mesenteric lymphatic vessel dysfunction and development of obesity/metabolic syndrome
Gasheva OY, et al.
The American Journal of Physiology, 316(1), G217-G217 (2019)
Nicholas Cutrona et al.
ACS infectious diseases, 5(8), 1397-1410 (2019-05-28)
Staphylococcus epidermidis and Staphylococcus aureus are important human pathogens responsible for two-thirds of all postsurgical infections of indwelling medical devices. Staphylococci form robust biofilms that provide a reservoir for chronic infection, and antibiotic-resistant isolates are increasingly common in both healthcare
Tomomi Aida et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(7), 1569-1579 (2015-02-11)
An increase in the ratio of cellular excitation to inhibition (E/I ratio) has been proposed to underlie the pathogenesis of neuropsychiatric disorders, such as autism spectrum disorders (ASD), obsessive-compulsive disorder (OCD), and Tourette's syndrome (TS). A proper E/I ratio is
Exposure-based validation of an in vitro gastrulation model for developmental toxicity assays
Warkus ELL and Marikawa Y
Toxicological Sciences, 157(1), 235-245 (2017)
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