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A5752

Sigma-Aldrich

Adrenochrome

>95% purity (HPLC), powder

Synonym(s):

3-Hydroxy-1-methyl-5,6-indolinedione

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$73.70
250 MG
$461.00

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Estimated to ship onApril 28, 2026FromMILWAUKEE


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25 MG
$73.70
250 MG
$461.00

About This Item

Empirical Formula (Hill Notation):
C9H9NO3
CAS Number:
Molecular Weight:
179.17
EC Number:
MDL number:
UNSPSC Code:
12171500
PubChem Substance ID:
NACRES:
NA.47

$73.70


Estimated to ship onApril 28, 2026FromMILWAUKEE


Request a Bulk Order

Product Name

Adrenochrome, ≥95% (HPLC)

Quality Level

assay

≥95% (HPLC)

form

powder

color

red to brown

εmax

3-4.5 at 485-490 nm in water
9.0-10.5 at 299-304 nm in water

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

−20°C

SMILES string

CN1CC(O)C2=CC(=O)C(=O)C=C12

InChI

1S/C9H9NO3/c1-10-4-9(13)5-2-7(11)8(12)3-6(5)10/h2-3,9,13H,4H2,1H3

InChI key

RPHLQSHHTJORHI-UHFFFAOYSA-N

Application

Adrenochrome has been used to study the effect of adrenochrome on coronary artery constriction in the rat heart.[1]

Biochem/physiol Actions

Adrenochrome is an oxidation product of adrenaline.[2] It has been implicated in cardiotoxicity.[3][4] It is a short-lived cytotoxic molecule and is part of the leukocyte response used to kill bacteria.[5] Adrenochrome is also suggested to exhibit psychotomimetic effects.[6] It is used to determine superoxide dismutase activity.[7]

related product

Product No.
Description
Pricing

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Cardiotoxicity of adrenochrome in isolated rabbit hearts assessed by epicardial NADH fluorescence.
Rump AF, et al.
Archives of Toxicology, 68, 571-571 (1994)
Ventricular dysfunction and necrosis produced by adrenochrome metabolite of epinephrine: relation to pathogenesis of catecholamine cardiomyopathy.
Yates JC, et al.
American Heart Journal, 102, 210-210 (1981)
Zhimin Tao et al.
Langmuir : the ACS journal of surfaces and colloids, 25(17), 10183-10188 (2009-05-27)
We have measured the influence of mesoporous silica (MCM-41 and SBA-15) nanoparticles and dense silica nanoparticles on epinephrine oxidation, a pH-dependent reaction, whose rate is small in acidic or neutral solutions but much greater at higher pH. The reaction was
Effect of Bacillus coagulans and B. firmus incorporated probiotic diet on Superoxide dismutase activity and catalase activity in Penaeus monodon.
Raghu P, et al.
World Scientific News, 44, 224-224 (2016)
Towards an adrenaline biosensor based on substrate recycling amplification in combination with an enzyme logic gate.
Molinnus D, et al.
Sensors and Actuators B, Chemical, 237, 190-195 (2016)

Questions

  1. Is this substance synthetic or naturally derived? Some download able Data on this product is dated 1/16/2023. Is this a relatively new substance?

    1 answer
    1. This substance is synthetic organic. The product has been offered previously before 2023. See below for an example of the Certificate of Origin.
      https://www.sigmaaldrich.com/coo/undefined/A5752/SHBL7005

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