A1887
Albumin from human serum
lyophilized powder, essentially fatty acid free
Synonym(s):
HSA
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About This Item
CAS Number:
EC Number:
MDL number:
UNSPSC Code:
12352202
eCl@ss:
42010201
NACRES:
NA.25
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biological source
human
Quality Level
assay
≥96% (agarose gel electrophoresis)
form
lyophilized powder
mol wt
monomer calculated mol wt 66478 Da
technique(s)
ELISA: suitable
tissue culture: suitable
western blot: suitable
impurities
HIV I and HIVII, HCV and HBsAg, tested negative
≤0.007% Fatty Acids
solubility
H2O: soluble 50 mg/mL, clear to slightly hazy
UniProt accession no.
storage temp.
2-8°C
InChI
1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
InChI key
QYSGYZVSCZSLHT-UHFFFAOYSA-N
Gene Information
human ... ALB(213)
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General description
Albumin is the most abundant plasma protein in human. It has a molecular weight of 66.5 kDa.
Application
Albumin from human serum has been used:
- as a carrier of CPT-11 (irinotecan, Campto) and SN-38 to investigate its binding to human plasma proteins
- to study the adsorption of water and acetonitrile (AN) vapor on a human serum albumin
- to study its effect on wound healing process
Biochem/physiol Actions
Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones, and is vital in regulating the colloidal osmotic pressures of blood. Albumin is also seen to bind to exogenous substances, particularly drugs (e.g., ibuprofen, warfarin), and strongly influence their pharmacokinetics. Oxidative stress leading to changes in the redox state of albumin has widely varied effects on its physiological function.
Serum albumin primarily mediates divalent cation transportation, fatty acid and drug complex formation and transport. The albumin levels in the serum indicate the disease progression in advanced liver disease. Low body weight and decreased serum albumin is associated with colorectal cancer.
Preparation Note
Prepared from albumin (A1653)
Other Notes
View more information on human serum albumin.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves
Certificates of Analysis (COA)
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The journal of physical chemistry. B, 117(37), 10798-10806 (2013-09-06)
This work demonstrates for the first time that binding of various compounds within subdomain IB of human serum albumin (HSA) provokes characteristic changes in the near-UV circular dichroism (CD) spectrum of the protein. It can be inferred from the spectroscopic
A J Crowle et al.
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In vitro binding and partitioning of irinotecan (CPT-11) and its metabolite, SN-38, in human blood
Combes O, et al.
Investigational New Drugs, 18(1), 1-5 (2000)
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