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P9672

Supelco

Probucol

analytical standard

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About This Item

Empirical Formula (Hill Notation):
C31H48O2S2
CAS Number:
23288-49-5
Molecular Weight:
516.84
EC Number:
245-560-9
MDL number:
MFCD00079281
UNSPSC Code:
41116107
PubChem Substance ID:
329820354
NACRES:
NA.24

grade

analytical standard

Quality Level

200

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

CC(C)(C)c1cc(SC(C)(C)Sc2cc(c(O)c(c2)C(C)(C)C)C(C)(C)C)cc(c1O)C(C)(C)C

InChI

1S/C31H48O2S2/c1-27(2,3)21-15-19(16-22(25(21)32)28(4,5)6)34-31(13,14)35-20-17-23(29(7,8)9)26(33)24(18-20)30(10,11)12/h15-18,32-33H,1-14H3

InChI key

FYPMFJGVHOHGLL-UHFFFAOYSA-N

Gene Information

human ... ABCA1(19) , IL1B(3553) , IL6(3569) , TNF(7124)

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General description

Probucol is a diphenolic compound possessing antioxidant and anti-inflammatory properties. It is commercially used as a lipid lowering drug, which helps in reducing the total plasma cholesterol, low density lipoprotein cholesterol (LDL) and high density lipoprotein cholesterol (HDL).

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Enhances selective uptake of HDL-associated cholesteryl esters.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SLCR4304
SLCM2132
SLBS3412V
SLBR2496V
MKBQ8447V

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Jonathan Watt et al.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 81(4), 698-708 (2012-05-15)
The aim of this study was to assess the efficacy of stent-based delivery of succinobucol alone and in combination with rapamycin in a porcine coronary model. Current drugs and polymers used to coat coronary stents remain suboptimal in terms of
Chang-Jiang Ge et al.
Chinese medical journal, 125(14), 2472-2476 (2012-08-14)
The plasma cystatin C concentration (PcyC) has been demonstrated to have prognostic value in acute coronary syndrome, but the study of PcyC in patients with borderline coronary lesions is limited. Moreover, the effects of atorvastatin and probucol on PcyC and
Eduardo Luiz Gasnhar Moreira et al.
Neuroscience letters, 541, 193-198 (2013-03-09)
Epidemiological studies indicate that high midlife plasma cholesterol levels increases the risk of Alzheimer's disease. Moreover, middle-aged familial hypercholesterolemia (FH) subjects show a particularly high incidence of mild cognitive impairments (MCI). These evidence points to hypercholesterolemia as one of the
Zhiwen Zhang et al.
International journal of pharmaceutics, 444(1-2), 162-168 (2013-01-24)
The therapeutic efficacy of lipophilic drugs is commonly restricted by the low systemic exposure after oral administration. In this work, a new delivery system combining the advantages of porous starch and self-assembled nanocarrier was designed to improve the oral absorption
Ryusuke Takechi et al.
Clinical and experimental pharmacology & physiology, 40(1), 45-52 (2012-11-22)
Dysfunction of the blood-brain barrier (BBB) is an early pathological feature of vascular dementia and Alzheimer's disease (AD) and is triggered by inflammatory stimuli. Probucol is a lipid-lowering agent with potent anti-oxidant properties once commonly used for the treatment of
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Articles

Cholesterol Transport

Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.

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