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Key Documents

P2428

Supelco

Proscillaridin A

analytical standard

Synonym(s):

3-(6-Deoxy-α-L-mannopyranosyloxyl)-14-hydroxybufa-4,20,22-trienolide, Scillarenin 3β-rhamnoside

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About This Item

Empirical Formula (Hill Notation):
C30H42O8
CAS Number:
Molecular Weight:
530.65
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:

grade

analytical standard

assay

≥80%

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages
forensics and toxicology
veterinary

format

neat

storage temp.

2-8°C

SMILES string

C[C@]12CC[C@]3([H])[C@@]4(C)CC[C@H](O[C@]5([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)C=C4CC[C@@]3([H])[C@@]1(O)CC[C@@H]2C6=COC(C=C6)=O

InChI

1S/C30H42O8/c1-16-24(32)25(33)26(34)27(37-16)38-19-8-11-28(2)18(14-19)5-6-22-21(28)9-12-29(3)20(10-13-30(22,29)35)17-4-7-23(31)36-15-17/h4,7,14-16,19-22,24-27,32-35H,5-6,8-13H2,1-3H3/t16-,19?,20?,21?,22?,24-,25+,26+,27-,28?,29?,30?/m0/s1

InChI key

MYEJFUXQJGHEQK-RLQJMXQZSA-N

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General description

Proscillaridin A may be used as a standard in the determination of proscillaridin A in the Scilla bifolia perennial herb extract, using thin layer chromatography (TLC) and high performance liquid chromatography coupled with mass spectrometry (HPLC).

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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R Schneider et al.
Clinical and experimental hypertension (New York, N.Y. : 1993), 20(5-6), 593-599 (1998-07-31)
A material crossreacting with antibodies against the bufadienolide proscillaridin A and inhibiting the sodium pump was found in human blood plasma. The concentration of the material with a retention time similar to ouabain in a reversed phase HPLC correlated to
A Sabouraud et al.
Human & experimental toxicology, 9(3), 191-193 (1990-05-01)
The purpose of this study was to evaluate the capacity of specific anti-digoxin Fab fragments to bind to and neutralize scilliroside and proscillaridin in acute poisoning. Apparent affinity constants were determined with values of 2.6 10(8)M-1 for scilliroside and 3.8
S Li et al.
Life sciences, 62(11), 1023-1033 (1998-03-27)
Besides an isomer of the cardenolide ouabain, a material with a similar HPLC retention time as ouabain but cross-reactivating with antibodies against the bufadienolide proscillaridin A and inhibiting the sodium pump is known to circulate in human blood plasma (B.
[A case of proscillaridin poisoning].
H Takahashi et al.
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 87(10), 2091-2092 (1998-12-29)
N Murakami et al.
Chemical & pharmaceutical bulletin, 39(8), 1962-1966 (1991-08-01)
The Diels-Alder reactions of a cardiac glycoside, proscillaridin (1), with some dienophiles were investigated. The reaction of 1 with alkenes such as methyl vinyl ketone and methyl acrylate afforded 3-oxo-2-oxabicyclo[2.2.2]oct-7-enes (2-5) and para-substituted benzene derivatives (6 and 7), while 1

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