A1028

8-Anilino-1-naphthalenesulfonic acid

≥97% purity (HPLC), powder

• Synonym(s): N-Phenyl peri acid, ANS, ANSA
• Linear Formula: C₆H₅NHC₁₀H₆SO₃H
• CAS Number: 82-76-8
• Molecular Weight: 299.34
• Beilstein/REAXYS Number: 1843887
• MDL number: MFCD00003998
• UNSPSC Code: 12171500
• PubChem Substance ID: 24890494
• NACRES: NA.47

Properties

• product name: 8-Anilino-1-naphthalenesulfonic acid,
• assay: ≥97% (HPLC)
• Quality Level: 200
• form: powder
• composition: , <0.5% (solvent)
• color: black; gray to dark green
• mp: 215-217 °C (dec.) (lit.)
• solubility: DMF: 50 mg/mL
• application(s): diagnostic assay manufacturing; hematology; histology
• storage temp.: room temp
• SMILES string: OS(=O)(=O)c1cccc2cccc(Nc3ccccc3)c12
• InChI: 1S/C16H13NO3S/c18-21(19,20)15-11-5-7-12-6-4-10-14(16(12)15)17-13-8-2-1-3-9-13/h1-11,17H,(H,18,19,20)
• InChI key: FWEOQOXTVHGIFQ-UHFFFAOYSA-N

Description

Application

8-Anilino-1-naphthalenesulfonic acid (ANS) has been used to study the thermal aggregation of BSA (bovine serum albumin).

Biochem/physiol Actions

8-Anilino-1-naphthalenesulfonic acid (ANS) is an important dye which is used to study the intermediate states in the folding/unfolding pathways of proteins. It is also useful to check the conformational changes involved with the aggregation of proteins. ANS is nonfluorescent in the aqueous solution, however, it fluoresces strongly upon binding to BSA (bovine serum albumin) and denatured proteins. It is used for the detection of albumin in the serum. ANS mainly interacts with the solvent exposed nonpolar (hydrophobic) sites.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable