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82551

Sigma-Aldrich

Pterine

≥97.0% (HPLC)

Synonym(s):

2-Amino-4-hydroxypteridine, 2-Amino-4-oxodihydropteridine

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About This Item

Empirical Formula (Hill Notation):
C6H5N5O
CAS Number:
2236-60-4
Molecular Weight:
163.14
Beilstein/REAXYS Number:
150294
EC Number:
218-799-1
MDL number:
MFCD00010557
UNSPSC Code:
12352202
PubChem Substance ID:
329769249

assay

≥97.0% (HPLC)

storage temp.

2-8°C

SMILES string

Nc1nc(O)c2nccnc2n1

InChI

1S/C6H5N5O/c7-6-10-4-3(5(12)11-6)8-1-2-9-4/h1-2H,(H3,7,9,10,11,12)

InChI key

HNXQXTQTPAJEJL-UHFFFAOYSA-N

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Other Notes

Review: Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin[1]

replaced by

Product No.
Description
Pricing

P1132

Pterine, ~95%

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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C l'Hélias et al.
Mutation research, 128(2), 147-152 (1984-09-01)
The experiments described in this paper show that synthetic pteridines, especially biopterin and pterin, injected directly into Drosophila melanogaster induce recessive lethals. On the contrary, D-neopterin seems to have little effect. A mutagenic effect has previously been shown for an
A S Lewis et al.
The Journal of biological chemistry, 259(1), 12-15 (1984-01-10)
We have examined the effects of folate compounds and the folate analog amethopterin (methotrexate) as inhibitors of mammalian xanthine oxidase and have found that they offer potent inhibition of the enzyme. We have compared the inhibitory potency of folic acid
Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin.
C A Nichol et al.
Annual review of biochemistry, 54, 729-764 (1985-01-01)
Matthew P Rubach et al.
PLoS pathogens, 11(3), e1004655-e1004655 (2015-03-13)
Decreased bioavailability of nitric oxide (NO) is a major contributor to the pathophysiology of severe falciparum malaria. Tetrahydrobiopterin (BH4) is an enzyme cofactor required for NO synthesis from L-arginine. We hypothesized that systemic levels of BH₄ would be decreased in
Daisuke Kadowaki et al.
Biological & pharmaceutical bulletin, 38(3), 487-492 (2015-03-12)
Uric acid exerts an important antioxidant effect against external oxidative stress under physiological conditions. However, uric acid itself can increase oxidative stress via reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation in adipocytes and vascular cells. Uric acid transporter 1
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