77460

2-Chloroacetophenone

purum, ≥98.0% (GC)

• Synonym(s): ω-Chloroacetophenone, Phenacyl chloride
• Linear Formula: C₆H₅COCH₂Cl
• CAS Number: 532-27-4
• Molecular Weight: 154.59
• Beilstein/REAXYS Number: 507950
• EC Number: 208-531-1
• MDL number: MFCD00000933
• UNSPSC Code: 12352100
• PubChem Substance ID: 329767699
• NACRES: NA.22
• form: crystals
• assay: ≥98.0% (GC)

Properties

• grade: purum
• Quality Level: 200
• assay: ≥98.0% (GC)
• form: crystals
• bp: 244-245 °C (lit.)
• mp: 53-56 °C; 54-56 °C (lit.)
• density: 1.324 g/mL at 25 °C (lit.)
• functional group: chloro; ketone; phenyl
• SMILES string: ClCC(=O)c1ccccc1
• InChI: 1S/C8H7ClO/c9-6-8(10)7-4-2-1-3-5-7/h1-5H,6H2
• InChI key: IMACFCSSMIZSPP-UHFFFAOYSA-N
• Gene Information: human ... PTPN6(5777)

Description

General description

2-Chloroacetophenone is an organic building block used in the synthesis of heterocyclic compounds. It has low solubility in water but can be soluble in alcohols, ethers and other organic solvents.

Application

2-Chloroacetophenone can be used in the synthesis of phenyl acetic acid by Photo-Favorskii rearrangement. It is also used in the preparation of 1-(2-chlorophenyl)ethanol via asymmetric hydrogenation reaction.

Safety Information

• pictograms: GHS06,GHS08,GHS05
• signalword: Danger
• hcodes: H300,H311 + H331,H315,H318,H334,H335
• pcodes: P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Eye Dam. 1 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges