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Supelco

Synephrine

analytical standard

Synonym(s):

1-(4-Hydroxyphenyl)-2-methylaminoethanol, 4-Hydroxy-α-(methylaminomethyl)benzyl alcohol

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About This Item

Empirical Formula (Hill Notation):
C9H13NO2
CAS Number:
Molecular Weight:
167.21
EC Number:
MDL number:
UNSPSC Code:
85151701
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

assay

≥98.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤12.0% water (Karl Fischer)

application(s)

food and beverages

format

neat

storage temp.

2-8°C

InChI

1S/C9H13NO2/c1-10-6-9(12)7-2-4-8(11)5-3-7/h2-5,9-12H,6H2,1H3

InChI key

YRCWQPVGYLYSOX-UHFFFAOYSA-N

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General description

Synephrine is a sympathomimetic amine from the plant Citrus aurantium and is identified as a major active component of dietary supplements.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Synephrine may be used as a reference standard for the determination of synephrine in dietary supplements using high-performance liquid chromatography with acidic potassium permanganate chemiluminescence detection.

Analysis Note

identification (GC-MS): identity conforms

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Determination of synephrine in weight-loss products using high performance liquid chromatography with acidic potassium permanganate chemiluminescence detection.
Slezak T, et al.
Analytica Chimica Acta, 593(1), 98-102 (2007)
Ischemic stroke associated with use of an ephedra-free dietary supplement containing synephrine.
Bouchard CN, et al.
Mayo Clinic Proceedings. Mayo Clinic, 80(4), 541-545 (2005)
Luciana Grazziotin Rossato et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 49(1), 8-16 (2010-11-16)
Synephrine is cited as 'the active component' of plants and dietary supplements used in weight loss. It became one of the most popular stimulants present in weight-loss products after the US Food and Drug Administration had interdicted the use of
Sidney J Stohs et al.
Oxidative medicine and cellular longevity, 2011, 482973-482973 (2011-09-10)
Bitter orange (Citrus aurantium) extract and its primary protoalkaloid p-synephrine are used widely in weight loss/weight management and sports performance products. Because of structural similarities, the pharmacological effects of p-synephrine are widely assumed to be similar to those of ephedrine
Sidney J Stohs et al.
Phytotherapy research : PTR, 25(10), 1421-1428 (2011-04-12)
Citrus aurantium (bitter orange) extract and its principal protoalkaloidal constituent p-synephrine are widely used in weight loss and weight management as well as in sports performance products. However, questions are raised frequently regarding the safety of these ingredients. The potential

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