68923

Esculetin

analytical standard

• Synonym(s): 6,7-Dihydroxycoumarin, Cichorigenin, Esculetin
• Empirical Formula (Hill Notation): C₉H₆O₄
• CAS Number: 305-01-1
• Molecular Weight: 178.14
• Beilstein/REAXYS Number: 152788
• EC Number: 206-161-5
• MDL number: MFCD00006874
• UNSPSC Code: 12352200
• PubChem Substance ID: 329761226
• NACRES: NA.24

Properties

• grade: analytical standard
• Quality Level: 100
• assay: ≥97.5% (HPLC); 97.5-102.5% (NT)
• shelf life: limited shelf life, expiry date on the label
• mp: 271-273 °C (lit.)
• format: neat
• SMILES string: Oc1cc2OC(=O)C=Cc2cc1O
• InChI: 1S/C9H6O4/c10-6-3-5-1-2-9(12)13-8(5)4-7(6)11/h1-4,10-11H
• InChI key: ILEDWLMCKZNDJK-UHFFFAOYSA-N

Description

General description

Esculetin is a derivative of coumarin, found in various plant species including Cichorium intybus (chicory), Bougainvillea spectabilis, Artemisia capillaris, etc and leaves of Citrus limonia (Rutaceae), Ceratostigma willmottianum, etc. It exhibits multiple pharmacological activities and is found to be a potent inhibitor of cyclooxygenase, 5-lipoxygenase, 12-lipoxygenase, catechol-O-methyl transferase, NADPH oxidase and xanthine oxidase enzymes.

Application

Esculetin may be used as an analytical reference standard for the determination of the analyte in biological and water samples by chromatography-based techniques. It may also be used as a standard in the quantification of the analyte in traditional herbal medicines by solid-phase extraction and micellar electrokinetic capillary methods, respectively.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable