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Supelco

Cirsilineol

analytical standard

Synonym(s):

4′,5-Dihydroxy-3′,6,7-trimethoxyflavone, 6-Methoxyluteolin 3′,7-dimethyl ether, Anisomelin, Eupatrin, Fastigenin

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About This Item

Empirical Formula (Hill Notation):
C18H16O7
CAS Number:
Molecular Weight:
344.32
Beilstein/REAXYS Number:
1355108
MDL number:
UNSPSC Code:
85151701
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

assay

≥95.0% (HPLC and enzymatic)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

SMILES string

COc1cc(ccc1O)C2=CC(=O)c3c(O)c(OC)c(OC)cc3O2

InChI

1S/C18H16O7/c1-22-13-6-9(4-5-10(13)19)12-7-11(20)16-14(25-12)8-15(23-2)18(24-3)17(16)21/h4-8,19,21H,1-3H3

InChI key

VKOSQMWSWLZQPA-UHFFFAOYSA-N

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General description

Cirsilineol is a bioactive flavone isolated from the herb of Artemisia vestita Wall., widely used to treat a variety of inflammatory conditions such as contact dermatitis, rheumatoid arthritis and sepsis. Cirsilineol exhibits anti-proliferative activity, which is used against different cancer cells by inducing apoptosis.

Application

Cirsilineol may be used as an analytical reference standard for the quantification of the analyte in vervain samples and extracts of Teucrium polium using chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Chun-nian He et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 30(10), 761-763 (2005-08-04)
To study the chemical constituents of Anoectochilus roxburghii. Silica gel and sephadex LH-20 column chromotography were used in the isolation from the ethanol extracts of the whole plant, the compounds were determined on the basis of various modern spectroscopic analysis
H J Heo et al.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 8(3), 194-201 (2001-10-26)
Amyloid beta protein (Abeta)-induced free radical-mediated neurotoxicity is a leading hypothesis as a cause of Alzheimer's disease (AD). Abeta increased free radical production and lipid peroxidation in PC12 nerve cells, leading to apoptosis and cell death. The effect of 4',5-dihydroxy-3',6,7-trimethoxyflavone
Cirsilineol inhibits proliferation of cancer cells by inducing apoptosis via mitochondrial pathway
Sheng X, et al.
The Journal of Pharmacy and Pharmacology, 60(11), 39-44 (2008)
Xia Sheng et al.
The Journal of pharmacy and pharmacology, 60(11), 1523-1529 (2008-10-30)
Cirsilineol (4',5-dihydroxy-3',6,7-trimethoxyflavone) is a compound isolated from the herb of Artemisia vestita Wall (Compositae). In this study, we aimed at examining the anti-proliferative activity of cirsilineol against multiple types of cancer cells and the underlying mechanisms. Cirsilineol significantly inhibited proliferation
HPLC and UV-spectrophotometry analysis of flavonoids in spray-dried and freez-dried extracts of Teucrium polium L.(Lamiaceae)
Stefkov G, et al.
Macedonian pharmaceutical bulletin, 47(11), 39-44 (2012)

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