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65363

Supelco

(R)-(−)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride

for chiral derivatization, LiChropur, ≥99.0%

Synonym(s):

(R)-(−)-MTPA-Cl, Mosher’s acid chloride

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$596.00

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Estimated to ship onMarch 14, 2025FromSAINT LOUIS


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100 MG
$151.00
500 MG
$596.00

About This Item

Linear Formula:
C6H5C(OCH3)(CF3)COCl
CAS Number:
Molecular Weight:
252.62
Beilstein/REAXYS Number:
3591563
MDL number:
UNSPSC Code:
12000000
PubChem Substance ID:
NACRES:
NA.22

$151.00


Estimated to ship onMarch 14, 2025FromSAINT LOUIS


Request a Bulk Order

grade

for chiral derivatization

Quality Level

product line

ChiraSelect

assay

≥99.0% (AT)
≥99.0%

optical activity

[α]20/D −137±2°, c = 6.4% in carbon tetrachloride

optical purity

enantiomeric ratio: ≥99.5:0.5 (GC)

quality

LiChropur

technique(s)

HPLC: suitable

refractive index

n20/D 1.469
n20/D 1.47 (lit.)

bp

213-214 °C (lit.)

density

1.35 g/mL at 25 °C (lit.)

shipped in

wet ice

storage temp.

−20°C

SMILES string

CO[C@](C(Cl)=O)(c1ccccc1)C(F)(F)F

InChI

1S/C10H8ClF3O2/c1-16-9(8(11)15,10(12,13)14)7-5-3-2-4-6-7/h2-6H,1H3/t9-/m0/s1

InChI key

PAORVUMOXXAMPL-VIFPVBQESA-N

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General description

(R)-(-)-a-Methoxy-a-(trifluoromethyl)phenylacetyl chloride (Mosher′s acid chloride) is generally used as a chiral derivatizing agent. It is easily available in enantiomerically pure form. It can form diastereomers with both alcohols and amines.[1]

Application

It was used for derivatizing D-arabinitol and L-arabinitol samples for high performance thin layer chromatography (HPTLC) analysis for studying resolution of the diastereoisomer.[2]
Ready-to-use reagent for the determination of the enantiomeric purity of alcohols and amines after derivatization[3][4]; doi:10.1038/nprot.2007.354[5]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Please note that R(-)-MTPA-Cl is derived from S(-)-MTPA

Recommended products

Discover LiChropur reagents ideal for HPLC or LC-MS analysis

Legal Information

ChiraSelect is a trademark of Sigma-Aldrich Co. LLC
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

pictograms

Corrosion

signalword

Danger

hcodes

Hazard Classifications

Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk_germany

WGK 3

flash_point_f

192.2 °F - closed cup

flash_point_c

89 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


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Michael North
Principles and Applications of Stereochemistry, 112-112 (1998)
Characterization of GDP-alpha-D-arabinopyranose, the precursor of D-Arap in Leishmania major lipophosphoglycan.
Schneider, Pascal, Malcolm J. McConville, and M. A. Ferguson.
The Journal of Biological Chemistry, 269.28, 18332-18337 (1994)
S. Yamaguchi et al.
Asymmetric Synthesis, 1 (1983)
Michael North
Principles and Applications of Stereochemistry, 112-112 (1998)
J.A. Dale et al.
Journal of the American Chemical Society, 95, 512-512 (1973)

Questions

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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