Xenobiotica; the fate of foreign compounds in biological systems, 23(2), 155-167 (1993-02-01)
1. The enzymic C-oxygenation of N,N'-diphenylguanidine (DPG) to N-(4-hydroxyphenyl)-N'-phenylguanidine (4HPG) and the N-oxygenation of N,N'-bis-(pentafluorophenyl)-guanidine (BPG) to N"-hydroxy-N,N"-bis-(pentafluorophenyl)-guanidine (HBPG) is reported. 2. The metabolites were identified by t.l.c. and mass spectral analysis using synthetic reference compounds. 3. Rat and rabbit
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 6(2), 293-301 (1985-11-01)
The toxicity and mutagenicity of 1,3-diphenylguanidine (DPG) were monitored in Salmonella bacteria using the direct incorporation protocol. The test consisted of either direct incorporation of DPG or analysis of body fluid and faecal material derived from animals exposed to DPG.
During the period between January 1989 and 15 April 1994 allergy to chemical compounds present in rubber was found in 51 (15%) out of 339 patients with occupational dermatitis. In this group (20 workers of the metallurgical industry, 15 health
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