34042
Rafoxanide
PESTANAL®, analytical standard
Synonym(s):
3′-Chloro-4′-(4-chlorophenoxy)-3,5-diiodosalicylanilide
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About This Item
Empirical Formula (Hill Notation):
C19H11Cl2I2NO3
CAS Number:
Molecular Weight:
626.01
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
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grade
analytical standard
Quality Level
product line
PESTANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
agriculture
environmental
format
neat
SMILES string
Oc1c(I)cc(I)cc1C(=O)Nc2ccc(Oc3ccc(Cl)cc3)c(Cl)c2
InChI
1S/C19H11Cl2I2NO3/c20-10-1-4-13(5-2-10)27-17-6-3-12(9-15(17)21)24-19(26)14-7-11(22)8-16(23)18(14)25/h1-9,25H,(H,24,26)
InChI key
NEMNPWINWMHUMR-UHFFFAOYSA-N
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General description
Rafoxanide is a halogenated salicylanilide and an anthelmintic agent. It is widely used against fasciolosis and haemonchosis in sheep and cattle. It also finds applications as an adulticide for Fasciola hepatica and Fasciola gigantica.
Application
Rafoxanide may be used as a reference standard in the determination of rafoxanide in plasma and tissue samples using high-performance liquid chromatography (HPLC) coupled with an ultraviolet detector and thermospray − mass spectrometry.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
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Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Legal Information
PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Giuseppe Cringoli et al.
Parasitology research, 99(6), 700-705 (2006-06-02)
A clinical longitudinal field trial was conducted on a dairy sheep farm in southern Italy to assess the effectiveness of a novel anthelmintic treatment strategic scheme against Fasciola hepatica. The scheme utilizes a dual anthelmintic treatment (DAT), i.e., the use
Glutathione S-transferases as markers of salicylanilide resistance in isolates of Fasciola hepatica.
C M Miller et al.
International journal for parasitology, 24(4), 533-542 (1994-07-01)
A possible link between the level of glutathione S-transferase (GST, E.C. 2.5.1.18) activity and the development of salicylanilide resistance in Fasciola hepatica was investigated. Various isolates of F. hepatica with varying susceptibilities to salicylanilides were isolated and maintained in the
J H Boersema et al.
Veterinary parasitology, 68(4), 383-388 (1997-03-01)
A survey was conducted on the occurrence of anthelmintic resistance of trichostrongylids on commercial sheep farms in the highveld of Zimbabwe. On ten farms the efficacy of fenbendazole, levamisole and rafoxanide was tested by a faecal egg count reduction test.
C P Swarnkar et al.
Tropical animal health and production, 33(4), 305-312 (2001-07-28)
Monitoring anthelmintic resistance in strongyle nematodes by the faecal egg count reduction test and a commercial larval development assay on an organized sheep farm in the semi-arid area of Rajasthan revealed the emergence of resistance to benzimidazoles and rafoxanide and
H A El-Banna et al.
Parasitology research, 102(6), 1337-1342 (2008-02-26)
This study investigated the comparative serum disposition kinetics of ivermectin (IVM) after a single subcutaneous dose of 200 microg/kg body weight of IVM alone or in combination with an anthelmintic consisting of ivermectin and rafoxanide (200 microg/kg of IVM and
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