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MABT84

Sigma-Aldrich

Anti-Aggrecan Antibody, clone 1-C-6

clone 1-C-6, from mouse

Synonym(s):

Aggrecan core protein, Cartilage-specific proteoglycan core protein, CSPCP

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1-C-6, monoclonal

species reactivity

mouse, rat, bovine

technique(s)

immunohistochemistry: suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_071526

UniProt accession no.

P07897

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... ACAN(176)

General description

Aggregating chondroitin sulfate proteoglycan or aggrecan, is one of the most studied proteoglycans. Many individual monomers of aggrecan bind to hyaluronic acid to form an aggregate, the monomer is known as aggrecan. The aggregates are comprised of up to 100 monomers attached to a single chain of hyaluronic acid. The high content of negatively charged polysaccharide chains contributes to the osmotic swelling of cartilage and in combination with intact collagen fibers results in articular cartilage resistance to compressive forces and high tensile strength. Aggrecan is abundant in articular cartilage and compromises 10% of its dry weight.

Immunogen

Reduced and alkylated Aggrecan isolated from Swarm Rat Chondrosarcoma

Application

This Anti-Aggrecan Antibody, clone 1-C-6 is validated for use in IH, WB for the detection of Aggrecan.
Western Blot Analysis: 1 µg/mL from a representative lot detected Aggrecan on 10 µg of A1D4 protein fraction from Bovine tissue.

Quality

Evaluated by Immunohistochemistry in normal mouse cartilage and normal rat cartilage tissues.

Immunohistochemistry Analysis: A 1:1,000 dilution of this antibody detected Aggrecan in normal mouse cartilage and normal rat cartilage tissues.

Target description

Various

Physical form

Format: Purified

Analysis Note

Control
Normal mouse cartilage and normal rat cartilage tissues

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Takamitsu Maruyama et al.
Science advances, 8(48), eadd6172-eadd6172 (2022-12-01)
Skeletal precursors are mesenchymal in origin and can give rise to distinct sublineages. Their lineage commitment is modulated by various signaling pathways. The importance of Wnt signaling in skeletal lineage commitment has been implicated by the study of β-catenin-deficient mouse
Thomas H Ambrosi et al.
Cell stem cell, 20(6), 771-784 (2017-03-24)
Aging and obesity induce ectopic adipocyte accumulation in bone marrow cavities. This process is thought to impair osteogenic and hematopoietic regeneration. Here we specify the cellular identities of the adipogenic and osteogenic lineages of the bone. While aging impairs the

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