AB15928
Anti-Vitamin K dependent protein S Antibody
from rabbit, purified by affinity chromatography
Synonym(s):
protein S (alpha), protein S, alpha, protein Sa, vitamin K-dependent plasma protein S
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, rat, rhesus macaque, monkey
species reactivity (predicted by homology)
horse, chimpanzee, human
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... PROS1(5627)
General description
Vitamin K dependent protein S is an anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
Specificity
Monkey (93%) and Rat (93%) Rhesus Monkey (93%).
This antibody recognizes Vitamin K dependent protein S.
Immunogen
This antibody is generated from rabbits immunized with a KLH-conjugated linear peptide corresponding to residues surrounding the mature peptide region of Vitamin K dependent protein S.
Application
Detect Vitamin K dependent protein S using this Anti-Vitamin K dependent protein S Antibody validated for use in WB.
Immunoprecipitation Analysis: 1:50,000 dilution from a previous lot detected Vitamin K dependent protein S on 15 µg of normal mouse serum.
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Apoptosis - Additional
Quality
Evaluated by Western Blot in mouse liver tissue lysate.
Western Blot Analysis: : 1:1000 dilution of this antibody detected Vitamin K dependent protein S on 10 µg of mouse liver tissue lysate.
Western Blot Analysis: : 1:1000 dilution of this antibody detected Vitamin K dependent protein S on 10 µg of mouse liver tissue lysate.
Target description
Approx. 69-75 kDa
Physical form
Affinity purified
Purified rabbit polyclonal containing 0.1 M Tris-glycine, pH 7.4, 0.150 mM NaCl and 0.05% sodium azide.
Storage and Stability
Maintain refrigerated at 2-8°C for 1 year from date of receipt.
Analysis Note
Control
Mouse liver tissue lysate
Mouse liver tissue lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis.
Burstyn-Cohen, T; Heeb, MJ; Lemke, G
The Journal of Clinical Investigation null
Delphine Lumbroso et al.
Frontiers in immunology, 9, 358-358 (2018-03-17)
The complete resolution of inflammation requires the uptake of apoptotic polymorphonuclear cells (PMN) by local macrophages (efferocytosis) and the consequent reprogramming of the engulfing phagocytes to reparative and pro-resolving phenotypes. The tyrosine kinase receptors TYRO3, AXL, and MERTK (collectively named
Genetic dissection of TAM receptor-ligand interaction in retinal pigment epithelial cell phagocytosis.
Burstyn-Cohen, T; Lew, ED; Traves, PG; Burrola, PG; Hash, JC; Lemke, G
Neuron null
GAS6 is a key homeostatic immunological regulator of host-commensal interactions in the oral mucosa.
Maria Nassar et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(3), E337-E346 (2017-01-05)
The oral epithelium contributes to innate immunity and oral mucosal homeostasis, which is critical for preventing local inflammation and the associated adverse systemic conditions. Nevertheless, the mechanisms by which the oral epithelium maintains homeostasis are poorly understood. Here, we studied
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