Frataxin is a nuclear encoded protein that is found in the mitochondria. This protein is not well understood but may be involved with iron sulfur clusters. In humans the gene is localized on chromosome 9 and is highly conserved during evolution. The gene is expressed in every cell, although in varying levels in different tissues and during development. The specific function of Frataxin is still unknown, but it has been shown to play a role in iron metabolism. Studies have demonstrated that the deletion of the Frataxin gene in yeast results in iron accumulation in mitochondria and loss of respiration. Recombinant human Frataxin has been shown to bind iron in vitro, and increased mitochondrial iron levels have been observed in patients with Friedreich′s Ataxia (FRDA).
Specificity
Cat. # AB15080 recognizes Frataxin.
Immunogen
Epitope: mature chain
GST-tagged Frataxin corresponding to mature chain.
Application
Research Category Neuroscience
Research Sub Category Neurodegenerative Diseases
This Anti-Frataxin Antibody is validated for use in WB for the detection of Frataxin.
Quality
Routinely evaluated by Western Blot on Human heart lysates.
Western Blot Analysis: 1:1,000 - 1:10,000 dilution of this lot detected Frataxin on 10 ug of human heart lysate
Target description
Approx. 18 kDa
Physical form
Format: Purified
GST-depleted sera
Rabbit polyclonal serum in buffer containing 0.05% NaN3.
Storage and Stability
Stable for 1 year at -20ºC from date of receipt.
Analysis Note
Control Human heart lysate.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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