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Key Documents

ABC257

Sigma-Aldrich

Anti-EPHB4 Antibody

from rabbit, purified by affinity chromatography

Synonym(s):

Ephrin type-B receptor 4, Hepatoma transmembrane kinase, Tyrosine-protein kinase TYRO11

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

species reactivity (predicted by homology)

mouse (based on 100% sequence homology), bovine (based on 100% sequence homology), rat (based on 100% sequence homology)

technique(s)

western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... EPHB4(2050)

General description

Ephrin type-B receptor 4 (EPHB4) is also called Hepatoma transmembrane kinase, and Tyrosine-protein kinase TYRO11. EPHB4 is a receptor tyrosine kinase that together with EFNB2 is critical to heart morphogenesis and angiogenesis through the regulation of cell adhesion and cell migration. EPHB4 is expressed in placenta, kidney, liver, lung, pancreas, skeletal muscle, and heart, as well as primitive and myeloid hematopoietic cells.

Immunogen

KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human EPHB4.

Application

Detect EphB4 using this rabbit polyclonal antibody, Anti-EPHB4 Antibody validated for use in western blotting.

Quality

Evaluated by Western Blotting in PC3 tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected EPHB4 in 10 µg of PC3 tissue lysate.

Target description

~120 kDa observed. The calculated molecular weight is 108 kDa, however EPHB4 has been shown as a ~120 kDa band in western blots (Lee, Y. C., et al. (2005). BMC Cancer. 5(119):1-11).

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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José Carlos Rivera et al.
Investigative ophthalmology & visual science, 56(13), 7897-7907 (2015-12-17)
This study evaluated the effects of BIBF1120, a novel triple angiokinase inhibitor against pathological retinal neovascularization. BIBF1120 effect on development of the normal retinal vasculature was evaluated in Sprague-Dawley rat pups. Two models of ischemic oxygen-induced retinopathy (OIR) and the
Ling-Dan Dong et al.
Oncology letters, 13(4), 2109-2114 (2017-04-30)
Endometrial adenocarcinoma (EC) is one of the most frequently diagnosed types of endometrial cancer and is typically a consequence of continuous estrogen receptor stimulation. Erythropoietin-producing hepatocyte receptor B4 (EphB4) and its ligand ephrin-B2 have been reported to be overexpressed in

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