8.51061

2-Chlorotrityl chloride

Novabiochem^®

• Synonym(s): 2-Chlorotrityl chloride
• Empirical Formula (Hill Notation): C₁₉H₁₄Cl₂
• CAS Number: 42074-68-0
• Molecular Weight: 313.22
• MDL number: MFCD00040399
• UNSPSC Code: 12352107
• EC Index Number: 255-647-3
• NACRES: NA.22

Properties

• Quality Level: 200
• product line: Novabiochem^®
• assay: ≥95.0% (HPLC)
• form: powder
• manufacturer/tradename: Novabiochem^®
• mp: 133.0-137.0 °C
• application(s): peptide synthesis
• storage temp.: 2-30°C
• InChI: 1S/C19H14Cl2/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H
• InChI key: JFLSOKIMYBSASW-UHFFFAOYSA-N

Description

General description

Hyperacid-labile ester protecting group ^[1]. Introduced under extremely mild conditions by reacting together the acid, trityl chloride and DIPEA in DCM. Ideal for the protection of the C-terminal carboxylic acid group of C-terminal protected peptide fragments, monoprotection of diacids and as a general carboxylic acid protecting group in organic synthesis.


Associated Protocols and Technical Articles
Guide to Selection of Orthogonally-Protected Building Blocks for Fmoc SPPS

Literature references

^[1] P. Athanassopoulos, et al. (1995) Tetrahedron Lett., 36, 5645.

Linkage

Replaces: 01-63-0045

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Melting range (lower value): ≥ 133 °C
Melting range (upper value): ≤ 137 °C
Assay (HPLC, area%): ≥ 95.0 % (a/a)

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS05,GHS07
• signalword: Warning
• hcodes: H290 - H315 - H319 - H335
• pcodes: P234 - P261 - P264 - P271 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 8A - Combustible, corrosive hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable