555556
Rho Kinase Inhibitor VII
The Rho Kinase Inhibitor VII controls the biological activity of Rho Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
Rho Kinase Inhibitor VII, ROCK Inhibitor VII, Rho Kinase Inhibitor VII
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About This Item
Empirical Formula (Hill Notation):
C21H24N8
Molecular Weight:
388.47
UNSPSC Code:
12352200
Quality Level
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
color
light beige
solubility
DMSO: 1 mg/mL
water: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A cell-permeable triaminotriazine ROCK inhibitor (IC50 = 6 nM in a cell-free ROCK1 kinase assay) that affects 24 other commonly studied non-ROCK kinases only at much higher concentrations (IC50 >2 µM) and effectively blocks MCP-1-induced THP-1 cell migration (IC50 = 30 nM) in vitro. Subcutaneous injection (3-10 mg/kg) of ROCK Inhibitor VII and oral dosing (30 mg/kg) of Y-27632 (Cat. Nos. 688000 & 688001) are both reported to significantly reduce arterial blood pressure in a spontaneous hypertensive rat model in vivo.
A cell-permeable triaminotriazine ROCK inhibitor (IC50 = 6 nM in a cell-free ROCK1 kinase assay) that affects 24 other commonly studied non-ROCK kinases only at much higher concentrations (IC50 >2 µM) and effectively blocks MCP-1-induced THP-1 cell migration (IC50 = 30 nM) in vitro. Subcutaneous injection (3-10 mg/kg) of ROCK Inhibitor VII and oral dosing (30 mg/kg) of Y-27632 (Cat. Nos. 688000 & 688001) are both reported to significantly reduce arterial blood pressure in a spontaneous hypertensive rat model in vivo.
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Ho, K.K., et al. 2009. Bioorg. Med. Chem. Lett.19, 6027.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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