474705
Mevastatin, Sodium Salt
Carboxylate form of Mevastatin that is active in whole cells and in cell-free assays.
Synonym(s):
Mevastatin, Sodium Salt
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About This Item
Empirical Formula (Hill Notation):
C23H35O6 · Na
Molecular Weight:
430.51
UNSPSC Code:
51111800
NACRES:
NA.77
Recommended Products
Quality Level
assay
≥98% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
color
white
solubility
ethanol: 20 mg/mL
DMSO: 30 mg/mL
shipped in
ambient
Storage temp.
−20°C
General description
Carboxylate form of Mevastatin (Cat. No. 474700) that is active in whole cells and in cell-free assays.
Carboxylate form of Mevastatin (Cat. No. 474700) that is active in whole cells and in cell-free assays. Mevastatin is an antibiotic that acts as a potent inhibitor of HMG-CoA reductase. Suppresses Ras farnesylation and inhibits myoblast fusion. Causes cell cycle arrest in late G1 phase. Mevastatin may also induce bone morphogenic protein-2 (BMP-2).
Biochem/physiol Actions
Cell permeable: no
Primary Target
HMG-CoA reductase
HMG-CoA reductase
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Sugiyama, M., et al. 2000. Biochem. Biophys. Res. Commun.271, 88.
Endo, A. 1992. J. Lipid Res.33, 1569.
Endo, A. 1992. J. Lipid Res.33, 1569.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Mouhannad Malek et al.
Nature communications, 12(1), 2673-2673 (2021-05-13)
Vesicular traffic and membrane contact sites between organelles enable the exchange of proteins, lipids, and metabolites. Recruitment of tethers to contact sites between the endoplasmic reticulum (ER) and the plasma membrane is often triggered by calcium. Here we reveal a
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